| 广州市HIV感染者鼻腔携带MRSE与MSSE菌株的耐药谱及遗传特征比较 |
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| 引用本文： | 江慧敏1,李凌华2,李丽雅2,蔡卫平2,熊倩灵1,李树凡1,黄星谕1,叶家萍1,姚振江1. 广州市HIV感染者鼻腔携带MRSE与MSSE菌株的耐药谱及遗传特征比较[J]. 现代预防医学, 2020, 0(12): 2282-2286 |
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| 作者姓名： | 江慧敏1 李凌华2 李丽雅2 蔡卫平2 熊倩灵1 李树凡1 黄星谕1 叶家萍1 姚振江1 |
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| 作者单位： | 1.广东药科大学公共卫生学院，广东 广州510310；2.广州市第八人民医院感染科，广东 广州 510060 |
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| 摘 要： | 目的 比较广州市HIV感染者鼻腔携带耐甲氧西林表皮葡萄球菌(methicillin - resistant Staphylococcus epidermidis, MRSE)与甲氧西林敏感表皮葡萄球菌(methicillin sensitive Staphylococcus epidermidis, MSSE)的耐药谱及遗传特征。方法 于2017年6 - 8月，对广州市某医院艾滋病门诊1 001名HIV感染者鼻腔分离的表皮葡萄球菌进行药物敏感性试验及毒素基因、耐消毒基因、耐药基因检测。结果 分离鉴定出422株表皮葡萄球菌，包括309(73.22%)株MRSE，113(26.78%)株MSSE。MRSE菌株对青霉素、头孢西丁、红霉素、四环素、莫西沙星、复方新诺明这6种抗生素的耐药率高于MSSE，差异均有统计学意义。MRSE菌株的多重耐药率达77.99%，高于MSSE(36.28%)。MRSE菌株毒素基因pvl的检出率为9.06%，耐消毒基因qacA/B、smr的检出率分别为53.72%、11.33%，耐药基因aac(6’) - aph(2’)的检出率(63.75%)最高。结论 广州市HIV感染者鼻腔MRSE的检出率和多重耐药率高，MRSE耐药情况较MSSE严重；耐消毒基因qacA/B和耐药基因aac(6’) - aph(2’)的检出率高。
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| 关 键 词： | HIV 耐甲氧西林表皮葡萄球菌 甲氧西林敏感表皮葡萄球菌 分子特征 |
Comparison of drug-resistant spectrum and genetic features between MRSE and MSSE strains from nasal carriage among HIV-positive patients in Guangzhou |
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| JIANG Hui-min,LI Ling-hua,LI Li-ya,CAI Wei-ping,XIONG Qian-ling,LI Shu-fan,HUANG Xing-yu,YE Jia-ping,YAO Zhen-jiang. Comparison of drug-resistant spectrum and genetic features between MRSE and MSSE strains from nasal carriage among HIV-positive patients in Guangzhou[J]. Modern Preventive Medicine, 2020, 0(12): 2282-2286 |
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| Authors: | JIANG Hui-min LI Ling-hua LI Li-ya CAI Wei-ping XIONG Qian-ling LI Shu-fan HUANG Xing-yu YE Jia-ping YAO Zhen-jiang |
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| Affiliation: | *School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510310, China |
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| Abstract: | This study aimed to compare the drug-resistant spectrum and genetic features between Methicillin resistant Staphylococcus epidermidis(MRSE) and Methicillin-sensitive Staphylococcus epidermidis(MSSE) strains from nasal carriage among HIV-positive patients in Guangzhou. Methods From June to August 2017, all Staphylococcus epidermidis isolated from 1001 HIV-positive patients from an AIDS clinic in Guangzhou were tested for antibiotics sensitivity, toxin genes, disinfection-resistance genes and drug-resistance genes. Results A total of 422 strains were identified as Staphylococcus epidermidis, including 309(73.22%) MRSE and 113(26.78%) MSSE. Compared with MSSE, MRSE increased the drug-resistance risks of penicillin, cefoxitin, erythromycin, tetracycline, moxifloxacin, trimethoprim-sulfamethoxazole(P<0.05). The multi-drug resistance rate of MRSE strains(77.99%) was higher than MSSE(36.28%). For the MRSE strains, the detection rate of toxin gene pvl was 9.06%, and the detection rate of disinfection-resistant genes qacA/B and smr were53.72% and 11.33% respectively. The detection rate of the drug-resistant gene aac(6 ’)-aph(2’)(63.75%) was the highest among detected gene. Conclusion The nasal detection rate and multi-drug resistance rate of MRSE are high among HIVpositive patients in Guangzhou. The drug-resistance of MRSE is much more severe than that of MSSE. The detection rates of the disinfection-resistance gene qacA/B and the drug-resistance gene aac(6 ’)-aph(2’) are higher than others. |
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| Keywords: | HIV Methicillin-resistant Staphylococcus epidermidis Methicillin-sensitive Staphylococcus epidermidis Molecular characteristic |
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