| 抗精子抗体对复发性流产发病风险影响的Meta分析 |
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| 引用本文： | 王称,毛宝宏,杨杰,代志蓉,王剑,刘倩,王晶晶,刘婧婷. 抗精子抗体对复发性流产发病风险影响的Meta分析[J]. 现代预防医学, 2020, 0(15): 2871-2876 |
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| 作者姓名： | 王称 毛宝宏 杨杰 代志蓉 王剑 刘倩 王晶晶 刘婧婷 |
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| 作者单位： | 甘肃省妇幼保健院，甘肃 兰州 730050 |
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| 基金项目： | 甘肃省自然科学基金项目(17JR5RA027)；;甘肃省卫生行业科研计划项目(GSWSKY2018-54)； |
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| 摘 要： | 目的系统评价血清抗精子抗体与RSA的相关性。方法通过检索PubMed、Embase、WoS、The Cochrane Library、CBM、中国知网、维普、万方等数据库,收集血清AsAb对RSA影响的相关文献,检索截止时间为2020年4月3日。结果共纳入18篇文献,累计样本4937例,其中RSA组血清AsAb阳性率为20.66%,对照组抗体阳性率为3.97%。经随机效应模型合并分析,血清AsAb阳性增加了RSA的发病风险(OR=6.05, 95%CI:4.01～9.14,Z=8.57,P<0.001)。亚组分析显示,流产次数≥3次且AsAb阳性女性发生RSA的风险增加6.26倍(OR=6.26, 95%CI:2.68～14.60,Z=4.24,P<0.001)。流产孕周小于12周的女性发生RSA的风险增加7.09倍(OR=7.09, 95%CI:2.79～18.00,Z=4.12,P<0.001)。结论血清AsAb阳性增加了RSA的发病风险,其可能是RSA的致病原因。
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| 关 键 词： | 复发性流产 抗精子抗体 Meta分析 |
Influence of anti-sperm antibody on risk of recurrent spontaneous abortion: a meta-analysis |
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| WANG Cheng,MAO Bao-hong,YANG Jie,DAI Zhi-rong,WANG Jian,LIU Qian,WANG Jing-jing,LIU Jing-ting. Influence of anti-sperm antibody on risk of recurrent spontaneous abortion: a meta-analysis[J]. Modern Preventive Medicine, 2020, 0(15): 2871-2876 |
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| Authors: | WANG Cheng MAO Bao-hong YANG Jie DAI Zhi-rong WANG Jian LIU Qian WANG Jing-jing LIU Jing-ting |
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| Affiliation: | Gansu Provincial Maternity and Child-care Hospital, Lanzhou,Gansu 730050, China |
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| Abstract: | To systematically review the association between the anti － sperm antibody ( AsAb) and ＲSA. Methods PubMed，Embase，WoS，The Cochrane Library，CBM，CNKI，VIP，Wanfang database were searched to collect studies about the association between AsAb and RSA published before April 3，2020. Ｒesults A total of 18 literatures were included，involving 4937 individuals. The positive rate of AsAb was 20. 66% in RSA group and 3. 97% in control group. The combined analysis of random effect model showed that positive serum AsAb increased the risk of RSA ( OＲ = 6. 05，95% CI: 4. 01 －9. 14，Z = 8. 57，P ＜ 0. 001) . The subgroup analysis showed that women with positive AsAb and ≥3 abortions increased the risk of RSA by 6. 26 times ( OＲ = 6. 26，95% CI: 2. 68 － 14. 60，Z = 4. 24，P ＜ 0. 001) . Women aborted at less than 12 weeks of gestation increased the risk of RSA by 7. 09 times ( OＲ = 7. 09，95% CI: 2. 79 － 18. 00，Z = 4. 12，P ＜ 0. 001) . Conclusion Positive serum AsAb increases the risk of RSA，which may be the cause of RSA. |
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| Keywords: | Recurrent spontaneous abortion ( ＲSA) Anti － sperm antibody ( AsAb) Meta － analysis |
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