In vitro susceptibilities of Mycobacterium tuberculosis to 10 antimicrobial agents. |
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| Authors: | S K Byrne C E Crawford G L Geddes W A Black |
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| Affiliation: | Provincial Laboratory, British Columbia Centre for Disease Control, Vancouver, Canada. |
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| Abstract: | After preliminary in vitro screening of 10 antimicrobial agents against Mycobacterium tuberculosis, the MICs of the 6 most promising agents against 27 clinical isolates were determined by agar dilution. The two quinolone compounds tested (difloxacin and A-56620) were the most active, each inhibiting 50% of the strains at concentrations of 4 micrograms/ml. M. tuberculosis strains previously shown to be resistant to isoniazid, streptomycin, rifampin, or ethambutol were as susceptible to these quinolone compounds as susceptible strains. |
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