Antimicrobial Susceptibility of Haemophilus ducreyi |
| |
| Authors: | Gregory W. Hammond Chang Joo Lian John C. Wilt Allan R. Ronald |
| |
| Affiliation: | 2Department of Medical Microbiology University of Manitoba, Canada R3E OZ3;1Department of Medicine, University of Manitoba, Canada R3E OZ3;3Infectious Diseases, Health Sciences Centre, Winnipeg, Canada R3E OZ3 |
| |
| Abstract: | ![]()
The susceptibility of 19 isolates of Haemophilus ducreyi from a recent chancroid outbreak and four reference strains was determined in vitro to 13 antimicrobial agents. The rabbit intradermal test for virulence was positive for all of the local isolates, but not for the reference strains. The "nonvirulent" reference strains were inhibited by lower minimum inhibitory concentrations (MICs) of most agents tested. For the virulent isolates, the range of MICs (in micrograms per milliliter) of the following were: of vancomycin, 8 to 128; of polymyxin, 32 to 128; of cloxacillin, 32 to 64; of tetracycline, 0.5 to 32; of cephalothin, 4 to 8; of doxycycline, 0.25 to 8; and of kanamycin, 1 to 8. Three strains were resistant to penicillin and ampicillin (MIC >/= 128 mug/ml), and these three strains produced beta-lactamase. The remainder were susceptible to 4 mug/ml. All strains were susceptible to rifampin (MIC
|
| |
| Keywords: | |
|
|
