| 化瘀通阳方药对UC大鼠L/M值及P选择素影响的观察 |
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| 引用本文： | 施丽婕,白洁琼,刘旭,郝冉. 化瘀通阳方药对UC大鼠L/M值及P选择素影响的观察[J]. 天津中医药大学学报, 2017, 34(5): 331-335 |
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| 作者姓名： | 施丽婕 白洁琼 刘旭 郝冉 |
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| 作者单位： | 天津中医药大学第一附属医院脾胃科, 天津 300193,天津中医药大学附属武清中医院, 天津 301700,天津市人民医院内窥镜室, 天津 300121,秦皇岛市中医医院脾胃科, 秦皇岛 066000 |
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| 基金项目： | 国家自然科学基金资助项目（81373848）。 |
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| 摘 要： | [目的]观察化瘀通阳方药对溃疡性结肠炎（UC）大鼠乳果糖/甘露醇值（L/M值）及P-选择素的影响，并探讨二者可能的关系。[方法]采用葡聚糖硫酸钠法进行UC大鼠模型的制作，分别予化瘀通阳方药灌肠及美沙拉嗪灌肠治疗，比较造模及治疗前后乳果糖/甘露醇值（L/M值）及P-选择素。[结果]造模后，大鼠L/M值及P-选择素较造模前明显增高，经化瘀通阳方药灌肠治疗，二者均明显减低，且与美沙拉嗪灌肠组相比，无统计学差异。[结论]化瘀通阳方药可有效降低UC模型大鼠L/M值及P-选择素，且与美沙拉嗪灌肠疗效相当。
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| 关 键 词： | 化瘀通阳方 溃疡性结肠炎 乳果糖/甘露醇值 P选择素 |
| 收稿时间： | 2016-09-13 |
Study on the effect of removing stasis and diffusing yang therapy to LMR and P-selectin of ulcerative colitis rats |
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| SHI Li-jie,BAI Jie-qiong,LIU Xue and HAO Ran. Study on the effect of removing stasis and diffusing yang therapy to LMR and P-selectin of ulcerative colitis rats[J]. Journal of Tianjin University of Traditonal Chinese Medicine, 2017, 34(5): 331-335 |
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| Authors: | SHI Li-jie BAI Jie-qiong LIU Xue HAO Ran |
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| Affiliation: | Spleen and Stomach Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Affiliated Wuqing Hospital of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301700, China,Endoscopy Room, Tianjin People''s Hospital, Tianjin 300121, China and Spleen and Stomach Department, Qinhuangdao City Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China |
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| Abstract: | [Objective] Observed the effect of removing stasis and diffusing yang therapy to LMR and P-selectin of ulcerative colitis rats, while analysis the relationship between the intestinal permeability and P-selectin level.[Methods] Ulcerative colitis model rats were made by DSS, mesalazine enema liquid and removing stasis and diffusing yang (RSDY) herbs in retention edema. The data of L/M and P-sel level were compared aftermolding and before and fater treatment.[Results] It was obviously found that L/M and P-sel level of the model replication group significantly increased comparing with the data of the normal group. The datas of L/M and P-sel level of the group treated by mesalazine and RSDY herbs was obviously less than the data of the model control group, while there was no significant difference between two groups.[Conclusion] Removing stasis and diffusing yang herbs retention enema can reduce L/M and P-sel level of the ulcerative colitis rats, while there was no statistically significant difference comparing with mesalazine group. |
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| Keywords: | resolving stasis and diffusing yang therapy ulcerative colitis L/M P-sel |
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