| 隐孢子虫感染模型及体外培养研究进展 |
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| 引用本文： | 尹建海,沈玉娟,曹建平. 隐孢子虫感染模型及体外培养研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2010, 28(5): 387-392 |
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| 作者姓名： | 尹建海 沈玉娟 曹建平 |
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| 作者单位： | 中国疾病预防控制中心寄生虫病预防控制所,卫生部寄生虫病原与媒介生物学重点实验室,世界卫生组织疟疾、血吸虫病和丝虫病合作中心,上海 200025 |
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| 摘 要： | 隐孢子虫是一种重要的人兽共患寄生原虫,能引起婴幼儿和免疫低下人群及动物以胃肠道腹泻为主的严重消化道疾病。隐孢子虫动物感染模型和体外培养体系的建立,为隐孢子虫的生长发育过程、免疫学、疫苗研究、药物筛选和疗效考核以及卵囊灭活技术提供了良好的基础。本文就近年来隐孢子虫的动物感染模型和体外培养体系的发展及其应用情况作一综述。
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| 关 键 词： | 隐孢子虫 动物模型 体外培养 应用 |
Progress on the application of Cryptoporidium infected animal models and in vitro cultivation |
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| YIN Jian-hai,SHEN Yu-juan,CAO Jian-ping. Progress on the application of Cryptoporidium infected animal models and in vitro cultivation[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2010, 28(5): 387-392 |
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| Authors: | YIN Jian-hai SHEN Yu-juan CAO Jian-ping |
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| Affiliation: | National Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology, MOH; WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China |
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| Abstract: | The genus Cryptosporidium is composed of protozoan parasites that infect epithelial cells in the microvillus border of the gastrointestinal tract of all classes of vertebrates, and cause severe diarrheal disease in a variety of neonatal animals, children and immunocompromised persons. Establishment of Cryptosporidium infected animal models and its in vitro cultivation system have established a good foundation for characterizing life cycle stage, exploring immunological mechanism, developing vaccines, screening and evaluating potential drugs, as well as assessing oocyst inactivation techniques. This paper reviews recent development and application of the Cryptosporidium infected animal models and its in vitro cultivation. |
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| Keywords: | Cryptosporidium Animal model In vitro cultivation Application')" >Cryptosporidium Animal model In vitro cultivation Application |
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