| 妊娠期妇女检测弓形虫感染的临床研究 |
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| 引用本文： | 朱民, 蔡黎, 马杏宝. 上海市2003—2010年孕妇弓形虫感染筛查状况分析[J]. 上海预防医学, 2017, 29(6): 474-477. DOI: 10.19428/j.cnki.sjpm.2017.06.013 |
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| 作者姓名： | 朱民 蔡黎 马杏宝 |
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| 作者单位： | 上海市疾病预防控制中心，上海 200336 |
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| 摘 要： | 目的了解上海市弓形虫检测方法和试剂盒使用情况，分析孕妇弓形虫感染状况，为本市弓形虫病的监测防治提供依据。方法收集2003—2010年上海市孕妇弓形虫感染筛查的方法和结果资料，分析孕妇弓形虫感染筛查情况。结果2003—2010年全市30家医疗单位开展了孕妇弓形虫感染筛查检测工作，共检测717 391人次，抗体总阳性比例为1.46%，其中IgG和IgM阳性比例分别为2.46%(1.48%~4.96%)和0.83%(0.38%~1.48%)。IgM单项阳性和IgG、IgM双项阳性占41.74%。春、夏季节弓形虫抗体阳性比例高于秋、冬季节；不同性质和等级的医疗单位弓形虫抗体阳性检出比例不等。上海市应用较多的弓形虫抗体检测方法为酶联免疫吸附试验和化学发光法，且对弓形虫IgG和IgM抗体阳性检出比例不同；进口检测试剂盒筛检弓形虫IgM抗体阳性比例较高，而国产检测试剂盒筛检弓形虫IgG抗体阳性比例较高。结论上海市2003—2010年孕妇弓形虫抗体水平与以往调查结果接近，IgM抗体阳性比例较高，应引起重视。各医疗单位要建立相应的质量控制体系，选用质量稳定可靠的检测试剂盒，避免引起漏诊和误诊。
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| 关 键 词： | 弓形虫 孕妇 筛查 |
| 收稿时间： | 2016-12-19 |
Toxoplasma gondii:from animals to humans |
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| Min ZHU, Li CAI, Xing-bao MA. Screening situation analysis on pregnant woman toxoplasma gondii infection in 2003-2010 in Shanghai[J]. Shanghai Journal of Preventive Medicine, 2017, 29(6): 474-477. DOI: 10.19428/j.cnki.sjpm.2017.06.013 |
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| Authors: | Min ZHU Li CAI Xing-bao MA |
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| Affiliation: | Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China |
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| Abstract: | ObjectiveTo ascertain the usage of Toxoplasma Gondii(T. gondii) test kit, and analyze the trends of T. gondii infection in Shanghai pregnant women so as to provide scientific evidence for effective intervention measures to prevent congenital toxoplasmosis.MethodsThe data were collected on methods and results of screening T. gondii infection in pregnant women in Shanghai from 2003 to 2010, and analysis of T. gondii infection was made on pregnant women in this city.ResultsDuring 2003 and 2010, in 30 hospitals of the City was carried out the screening test for pregnant women T. gontii infection. The overall serological positive rate to T. gondii was 1.46% from the 30 hospitals. The positive rates of IgG antibody was 2.46%(1.48%-4.96%) in 277 523 persons, that of IgM antibody was 0.83%(0.38%-1.48%) in 439 868 persons. The IgM or both IgG and IgM positive pregnancy cases accounted for 41.74% of the total positive cases which appeared in pregnant women from 2008 to 2010. There were also significant differences in the positive rates in different hospitals and so as in different seasons. ELISA and MEIA were more detected for T. gondii antibody detection, and their detection rates of IgG and IgM were significantly different. The imported kit has higher positive rate of detection T. gondii IgM antibody, but lower positive rate of screening IgG antibody than the domestic kit.ConclusionThe seroprevalence of T. gondii in pregnant women from 2003 to 2010 were close to the average level investigated in the past in Shanghai, but more attention should be paid to the higher proportion of IgM antibody positive, and stable and reliable test kits should be selected for detecting T. gondii IgG and IgM antibodies to avoid leak and mistaken diagnosis. |
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| Keywords: | Toxoplasma gondii pregnancy women screening |
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