Autoproliferation in HIV-1-infected patients undergoing active HIV-1-specific immunotherapy. |
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| Authors: | R J Trauger W Giermakowska S Wormsley J Turner F C Jensen D J Carlo |
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| Affiliation: | Immune Response Corporation, Carlsbad, CA, USA. |
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| Abstract: | We have observed a treatment-associated autoproliferative response in cultured peripheral blood mononuclear cells (PBMC) of asymptomatic HIV-1-infected subjects receiving a gp120-depleted, inactivated HIV-1 antigen in incomplete Freund's adjuvant (IFA; HIV-1 Immunogen). The frequency and magnitude of the autoproliferative response appeared to be dose-related (P < 0.05), and was not observed in subjects receiving IFA alone. Immunophenotyping of the proliferating cells demonstrated the presence of both CD4+ and CD8+ lymphocytes, with the CD4+ blasts almost exclusively expressing the CD45RO+ phenotype. A comparison of this response with the HIV-1-specific antigen stimulation responses in this cohort revealed a significant correlation between increases in HIV-1-specific cell-mediated immunity and autoproliferation (r2 = 0.61, P < 0.001). These findings suggest that immunization with the HIV-1 Immunogen induces an autoproliferative response that may reflect changes in HIV-1-specific cell-mediated immunity in infected individuals. |
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| Keywords: | HIV-1 Immunogen immunotherapy autoproliferation HIV-1 cell-mediated immunity |
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