| 帕瑞昔布超前镇痛有效缓解妇科门诊手术术后疼痛的随机对照研究 |
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| 引用本文： | 李春晶,;于小兰,;王东信,;曲元,;刘佳,;穆东亮. 帕瑞昔布超前镇痛有效缓解妇科门诊手术术后疼痛的随机对照研究[J]. 中国药学, 2014, 23(9): 654-659. DOI: 10.5246/jcps.2014.09.084 |
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| 作者姓名： | 李春晶, 于小兰, 王东信, 曲元, 刘佳, 穆东亮 |
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| 作者单位： | [1]北京大学第一医院麻醉科,北京100034; [2]北京大学第一医院计划生育中心,北京100034; [3]北京大学第一医院妇产科手术室,北京100034 |
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| 摘 要： | 帕瑞昔布超前镇痛在妇科门诊手术后疼痛治疗的作用一直没有完全阐明。本研究目的是观察帕瑞昔布超前镇痛是否能够减少妇科门诊手术后疼痛。200名准备接受妇科门诊手术的女患者随机分成两组：试验组在麻醉诱导前30分钟静脉给予40 mg帕瑞昔布,对照组给予生理盐水。用VAS评分系统（视觉模拟评分系统,0 mm=无痛,100 mm=最痛）做疼痛评分。帕瑞昔布组疼痛评分明显低于对照组？帕瑞昔布组术中低氧血症发生率也明显降低？术毕恢复到睁眼和能够回忆起出生日期的时间也明显缩短。帕瑞昔布组患者满意度也远远大于对照组。
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| 关 键 词： | 帕瑞昔布 术后疼痛 门诊手术 妇科 |
| 收稿时间： | 2014-03-24 |
Parecoxib pretreatment effectively relieved pain after ambulatory gynecological surgery: a randomized controlled trial |
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| Chunjing Li,Xiaolan Yu,Dongxin Wang,Yuan Qu,Jia Liu,Dongliang Mu. Parecoxib pretreatment effectively relieved pain after ambulatory gynecological surgery: a randomized controlled trial[J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(9): 654-659. DOI: 10.5246/jcps.2014.09.084 |
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| Authors: | Chunjing Li Xiaolan Yu Dongxin Wang Yuan Qu Jia Liu Dongliang Mu |
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| Affiliation: | Chunjing Li, Xiaolan Yu, Dongxm Wang , Yuan Qu, Jia Liu, Dongliang Mu ( 1. Departments of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China 2. Department of Gynecology planning eare ward, Peking University First Hospital, Beijing 100034, China 3. Gynecological Operating Center, Peking University First Hospital, Beijing 100034, China) |
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| Abstract: | Although parecoxib plays an important role in pain management after ambulatory gynecological surgery, its exact effect remains to be fully elucidated. In the present study, we aimed to investigate the effect of parecoxib pretreatment in reducing pain intensity after ambulatory gynecological surgery. A total of 200 female patients who were scheduled to selective ambulatory gynecological surgery were randomly divided into two groups. Patients in the control group received normal saline as placebo, whereas 40 mg parecoxib was given to the patients in the parecoxib group 30 min prior to anesthesia induction. Visual analogue score （0 mm = no pain, and 100 mm= most severe pain） was used to evaluate postoperative pain severity. Pain scores were significantly lower in the parecoxib group than those in the control group after surgery. Compared with the control group, the incidence of intraoperative hypoxemia was significantly lower, and the recovery time from end of anesthesia to eye opening and birth date recollection were significantly shorter in the parecoxib group. Patients in the parecoxib group also had significantly improved overall satisfaction than those in the control group. |
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| Keywords: | Parecoxib Postoperative pain Ambulatory surgery Gynecology |
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