| 一个氢化橙酮衍生物的全合成 |
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| 引用本文： | 宋爱丽,;王超,;吴艳芬,;周立东. 一个氢化橙酮衍生物的全合成[J]. 中国药学, 2014, 23(10): 688-693. DOI: 10.5246/jcps.2014.10.088 |
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| 作者姓名： | 宋爱丽, 王超, 吴艳芬, 周立东 |
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| 作者单位： | [1]中国医学科学院北京协和医学院、药用植物研究所,北京100193; [2]北京大学医学部药学院药物化学系,北京100191 |
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| 摘 要： | 本文以2．4％的总收率首次全合成了一个氢化橙酮衍生物，即4-甲氧基-2，6-二羟基-2-苄基-3（2H）-苯并呋喃酮。以问苯三酚为起始原料，该合成工作涉及的关键反应包括：傅克酰基化、Williamson关环、催化氢化、羟醛缩合、烯醇化以及Rubottom氧化反应等。
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| 关 键 词： | 氢化橙酮 全合成 杨树胶 |
| 收稿时间： | 2014-06-04 |
Total synthesis of a hydrated aurone derivative |
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| Aili Song,Chao Wang,Yanfen Wu,Lidong Zhou. Total synthesis of a hydrated aurone derivative[J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(10): 688-693. DOI: 10.5246/jcps.2014.10.088 |
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| Authors: | Aili Song Chao Wang Yanfen Wu Lidong Zhou |
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| Affiliation: | Aili Song, Chao Wang, Yanfen Wu, Lidong Zhou(. 1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 2. Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191. China) |
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| Abstract: | The total synthesis of a hydrated aurone derivative, 2-benzyl-4-methoxy-2,6-dihydroxybenzofuran-3（2H）-one, has been achieved for the first time with 2.4% overall yield. Using phloroglucinol as the starting material, the key steps included Friedel-Crafts acylation, Williamson synthesis, hydrogenolysis, aldol condensation, enolization and Rubottom oxidation. |
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| Keywords: | Hydrated aurone Total synthesis Poplar gum |
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