| 冬凌草甲素固体分散体的制备及溶解性能研究 |
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| 引用本文： | 尚校军, 董若怡, 马素英, 底雪梅. 冬凌草甲素固体分散体的制备及溶解性能研究[J]. 中国现代应用药学, 2010, 27(5): 418-421. |
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| 作者姓名： | 尚校军 董若怡 马素英 底雪梅 |
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| 作者单位： | 1.新乡医学院药学院，河南 新乡 453003 |
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| 摘 要： | 目的 采用固体分散技术，提高冬凌草甲素的体外溶解性能。方法 分别以聚乙二醇6000(PEG6000)、聚乙烯吡咯烷酮K30(PVPK30)为载体，制备冬凌草甲素固体分散体。采用紫外分光光度法进行含量测定，差示热分析法鉴别药物在载体中的存在状态，并进行溶解度、体外溶出速率实验。结果 两种载体的固体分散体均能增加药物的溶解度和溶出速率，冬凌草甲素在载体中以高度分散状态存在。结论 以 PVPK30为载体制备的冬凌草甲素固体分散体体外溶解度和溶出速率明显提高。
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| 关 键 词： | 冬凌草甲素 固体分散体 溶解度 溶出速率 差示热分析 |
Studies on Preparation and Dissolution of Oridonin Solid Dispersions |
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| SHANG Xiaojun, DONG Ruoyi, MA Suying, DI Xuemei. Studies on Preparation and Dissolution of Oridonin Solid Dispersions[J]. Chinese Journal of Modern Applied Pharmacy, 2010, 27(5): 418-421. |
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| Authors: | SHANG Xiaojun DONG Ruoyi MA Suying DI Xuemei |
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| Affiliation: | 1.Pharmacy College, Xinxiang Medical University, Xinxiang, 453003, China |
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| Abstract: | OBJECTIVE To prepare and characterize the solid dispersions(SDs) with improved solubility and dissolution rates of oridonin.METHODS The SDs were prepared with polyethyleneglycol 6000(PEG6000) and polyvinylpyrrolidone K30(PVPK30) as carriers respectively.UV-spectrophotometry was used to determine the contents of oridonin.The physical and chemical properties of SDs,starting material and physical mixtures were investigated by differential thermal analysis(DTA) and dissolution rate in vitro.The solubilities wer... |
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| Keywords: | oridonin solid dispersion solubility dissolution rate differential thermal analysis |
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