Efficacy of LY333328 against Experimental Methicillin-Resistant Staphylococcus aureus Endocarditis |
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| Authors: | Glenn W. Kaatz Susan M. Seo Jeffrey R. Aeschlimann Heather H. Houlihan Renee-Claude Mercier Michael J. Rybak |
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| Affiliation: | Department of Internal Medicine, Division of Infectious Diseases, School of Medicine,1. Department of Veteran’s Affairs Medical Center,2. and College of Pharmacy and Allied Health Professions,3. Wayne State University, and Anti-Infective Research Laboratory, Department of Pharmacy Services, Detroit Receiving Hospital and University Health Center,4. Detroit, Michigan 48201 |
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| Abstract: | The in vivo efficacy of LY333328, a new glycopeptide antibiotic, was compared with that of vancomycin by using the rabbit model of left-sided methicillin-resistant Staphylococcus aureus endocarditis. Animals received LY333328 or vancomycin (25 mg/kg of body weight every 24 or 8 h, respectively) for 4 days. These drugs were equally effective in clearing bacteremia and in reducing bacterial counts in vegetations and tissues. We conclude that in this model, LY333328 was microbiologically effective and may be a therapeutic alternative to vancomycin. |
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