| 泛素蛋白酶体抑制剂在急性髓系白血病中的研究进展 |
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| 引用本文： | 肖方楠,张明英,周圆. 泛素蛋白酶体抑制剂在急性髓系白血病中的研究进展[J]. 中国医学科学院学报, 2022, 44(5): 868-875. DOI: 10.3881/j.issn.1000.503X.14299 |
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| 作者姓名： | 肖方楠 张明英 周圆 |
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| 作者单位： | 中国医学科学院 北京协和医学院 血液学研究所 血液病医院 实验血液学国家重点实验室 国家血液系统疾病临床医学研究中心,天津 300020 |
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| 基金项目： | 国家自然科学基金(81770128);国家自然科学基金(81970120) |
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| 摘 要： | 泛素蛋白酶体系统(UPS)在真核生物蛋白质循环中具有重要生物学作用，出现异常可导致肿瘤的发生。目前包括白血病在内的多种肿瘤患者体内均检测到高水平的泛素蛋白酶体活性。泛素蛋白酶体抑制剂通过影响泛素蛋白酶体系统的E3连接酶、去泛素化酶以及蛋白质降解活性位点能够有效地杀伤肿瘤细胞。临床上已经将相关泛素蛋白酶体抑制剂用于治疗血液系统肿瘤，但在急性髓系白血病中的应用相对较少。本文对影响蛋白质泛素化降解不同阶段的抑制剂在急性髓系白血病中的研究进展进行相关总结，为研发急性髓系白血病有效疗法提供新思路。
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| 关 键 词： | 泛素蛋白酶体系统 急性髓系白血病 泛素蛋白酶体抑制剂 |
| 收稿时间： | 2021-06-24 |
Research Progress of Ubiquitin Proteasome Inhibitors in Acute Myeloid Leukemia |
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| XIAO Fangnan,ZHANG Mingying,ZHOU Yuan. Research Progress of Ubiquitin Proteasome Inhibitors in Acute Myeloid Leukemia[J]. Acta Academiae Medicinae Sinicae, 2022, 44(5): 868-875. DOI: 10.3881/j.issn.1000.503X.14299 |
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| Authors: | XIAO Fangnan ZHANG Mingying ZHOU Yuan |
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| Affiliation: | State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Institute of Hematology & Blood Diseases Hospital,CAMS and PUMC,Tianjin 300020,China |
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| Abstract: | Ubiquitin-proteasome system (UPS) plays an essential role in eukaryotic protein cycle,the dysregulation of which can lead to tumorigenesis.Increased activities of UPS have been observed in the patients with cancers including leukemia.UPS inhibitors can kill cancer cells by affecting ubiquitin-ligating enzyme E3,deubiquitinase,and protein degradation active sites of UPS.Therefore,UPS inhibitors have emerged as an important therapy for treating hematological malignancies,while they are rarely applied in the treatment of acute myeloid leukemia.This paper summarizes the research progress in the inhibitors affecting the protein ubiquitination at different stages of acute myeloid leukemia,aiming to provide new clues for the clinical treatment of acute myeloid leukemia. |
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| Keywords: | ubiquitin-proteasome system acute myeloid leukemia ubiquitin-proteasome system inhibitor |
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