| 黑米花色苷对果糖喂养大鼠胰岛素敏感性影响 |
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| 引用本文： | 郭红辉, 胡艳, 刘驰, 王庆, 凌文华. 黑米花色苷对果糖喂养大鼠胰岛素敏感性影响[J]. 中国公共卫生, 2008, 24(10): 1200-1202. DOI: 10.11847/zgggws2008-24-10-27 |
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| 作者姓名： | 郭红辉 胡艳 刘驰 王庆 凌文华 |
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| 作者单位： | 1.韶关学院英东生物工程学院, 广东韶关512005;2.中山大学公共卫生学院 |
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| 摘 要： | 目的 观察黑米花色苷提取物(AEBR)对果糖喂养大鼠胰岛素敏感性的影响,并从c-Jun氨基端激酶(JNK)活化程度的变化分析其作用机制.方法 将48只SD大鼠分成4组,设置对照,向高果糖饲料中添加8周或4周的AEBR(5 g/kg饲料),检测各组大鼠胰岛素敏感性、脂肪组织胰岛素信号转导和JNK的活化情况.结果 AEBR能够预防和改善高果糖膳食引起的大鼠胰岛素抵抗,抑制其脂肪组织内JNK的活化,显著增加胰岛素刺激后胰岛素受体底物-1(IRS-1)的酪氨酸磷酸化和葡萄糖转运体-4(GLUT4)的易位(P<0.05).结论 AEBR可能是通过抑制JNK的活化来改善果糖喂养大鼠的胰岛素敏感性.
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| 关 键 词： | 黑米 花色苷 果糖 胰岛素抵抗 c-Jun氨基端激酶 |
| 收稿时间： | 2008-02-18 |
Effect of anthocyanin extracted from black rice on insulin sensitivity in fructose-fed rats |
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| GUO Hong-hui, HU Yan, LIU Chi, . Effect of anthocyanin extracted from black rice on insulin sensitivity in fructose-fed rats[J]. Chinese Journal of Public Health, 2008, 24(10): 1200-1202. DOI: 10.11847/zgggws2008-24-10-27 |
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| Authors: | GUO Hong-hui HU Yan LIU Chi |
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| Affiliation: | 1.Bioengineering of Yingdong College, Shaoguan University Shaoguan 512005, China |
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| Abstract: | Objective To investigate the effects and possible mechanisms of anthocyanin extracted from black rice(A EBR)on insulin sensitivity in fructose-induced insulin resistant rats.Methods A total of 48 rats were randomly divided into 4 groups fed with different diets for 8 weeks.Compared with the control group,the impact of A EBR on insulin sensitivity and activation of c-Jun NH2-terminal kinase(JNK)in fructose-fed rats supplemented with or without 5g/kg of A EBR was assessed.Results A EBR prevented and attenuated high-fructose-induced insulin resistance,reduced the activation of JNK and improved insulin transduction in adipose tissue of fructose-fed rats(P<0.05).Conclusion The improvement of insulin sensitivity by A EBR in fructose-fed rats is associated with the inhibition of JNK activation. |
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| Keywords: | black rice anthocyanin fructose insulin resistance c-Jun NH2-terminal kinase |
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