rpoB Gene mutations and molecular characterization of rifampin-resistant Mycobacterium tuberculosis isolates from Shandong Province, China |
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| Authors: | Ma Xin Wang Haiying Deng Yunfeng Liu Zhimin Xu Yong Pan Xi Musser James M Graviss Edward A |
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| Affiliation: | Kathearine Hsu Internation REsearch Center of Human Infectious Diseases, Shandong Provinical Tuberculosis Control Center, Jinan, Shandong, China. xma@bcm.edu |
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| Abstract: | Sixty rifampin (RIF)-resistant and 75 RIF-susceptible Mycobacterium tuberculosis isolates from Shandong Province, China, were analyzed for rpoB gene mutations and genotyped. Mycobacterial interspersed repetitive unit (MIRU) genotype 223325173533 was overrepresented among RIF-resistant isolates. MIRU combined with IS6110 restriction fragment length polymorphism analysis as the second-line genotyping method may reflect epidemiologic links more reliably than each method alone. |
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