Influence of dexamethasone on efficacy of ceftriaxone and vancomycin therapy in experimental pneumococcal meningitis. |
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| Authors: | C Cabellos, J Martinez-Lacasa, A Martos, F Tubau, A Fern ndez, P F Viladrich, F Gudiol |
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| Affiliation: | C Cabellos, J Martinez-Lacasa, A Martos, F Tubau, A Fernández, P F Viladrich, and F Gudiol |
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| Abstract: | Using a rabbit model of meningitis, we sought to determine whether concomitant use of dexamethasone affects the penetration and efficacy of ceftriaxone or vancomycin in cerebrospinal fluid. Rabbits were inoculated with a penicillin-sensitive strain of Streptococcus pneumoniae and treated with ceftriaxone or vancomycin with or without dexamethasone. In the ceftriaxone-treated groups, no statistically significant differences were seen between the group treated with dexamethasone and that without dexamethasone; however, in the vancomycin-treated groups we found statistically significant lower cerebrospinal fluid vancomycin levels at 2 h in the dexamethasone-treated rabbits and differences in bacterial killing. |
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