Noncoding RNAs as therapeutic targets in atherosclerosis with diabetes mellitus |
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| Authors: | Ningning Tang Shaoyan Jiang Yanyan Yang Shaoyan Liu Murugavel Ponnusamy Hui Xin Tao Yu |
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| Affiliation: | 1. Institute for Translational Medicine, Qingdao University, Qingdao, China;2. Department of Cardiology, The Affiliated Cardiovascular Hospital of Qingdao University, Qingdao, China;3. Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, China |
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| Abstract: | Atherosclerosis is one of the major macrovascular complications of diabetes mellitus (DM), and it is the main cause of death from clinical observation. Among various cell types involved in this disorder, endothelial cells, vascular smooth muscle cells (VSMCs), and macrophages play a crucial role in the occurrence and development of this disease. The regulation and stabilization of these cells are a key therapeutic strategy for DM‐associated atherosclerosis. An increasing number of evidences implicate that various types of noncoding RNAs (ncRNAs) play a vital role in many cellular responses as well as in physiological and pathological processes of atherosclerosis and DM that drive atherogenic/antiatherogenic processes in those cells. Encouragingly, many ncRNAs have already been tested in animal experiments or clinical trials showing good performance. In this review, we summarize recent progresses in research on functional regulatory role of ncRNAs in atherosclerosis with DM. More importantly, we illustrate new thoughts and findings relevant to ncRNAs as potential therapeutic targets or biomarkers for atherosclerosis with DM. |
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| Keywords: | biomarkers cardiovascular diabetes mellitus noncoding RNAs targets |
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