Activity attenuates skeletal muscle fiber damage after ischemia and reperfusion |
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| Authors: | Thomas J. Walters PhD Koyal Garg PhD Benjamin T. Corona PhD |
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| Affiliation: | Extremity Trauma and Regenerative Medicine Research Program, United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA |
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| Abstract: | Introduction: In this investigation we aimed to determine whether: (1) physical activity protects rat skeletal muscle from ischemia/reperfusion (I/R) injury; and (2) continued activity after I/R improves the rate of healing. Methods: Rats were divided into sedentary or active (voluntary wheel running) groups. Active rats ran for 4 weeks before I/R or 4 weeks before plus 4 weeks after I/R. Results: Activity before I/R resulted in 73.2% less muscle damage (Evans blue dye inclusion). Sedentary and active rats had a similar decline in neural‐evoked (～99%) and directly stimulated (～70%) in vivo muscle torque, and a similar reduction in junctophilin 1. Active rats produced 19% and 15% greater neural‐evoked torque compared with sedentary rats at 14 and 28 days postinjury, respectively, although the rate of recovery appeared similar. Conclusions: Activity protects against long‐term muscle damage, but not short‐term neural injury or excitation‐contraction uncoupling. Continued activity neither accelerates nor hinders the rate of functional recovery. Muscle Nerve 52: 640–648, 2015 |
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| Keywords: | exercise junctophilin 1 muscle injury rats trauma |
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