| 复方蒿甲醚片治疗间日疟的效果 |
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| 引用本文： | 李兴亮,李崇珍,车立刚,刘行知,李宗惠,黄德顺,何伟,刀清勇. 复方蒿甲醚片治疗间日疟的效果[J]. 中国寄生虫学与寄生虫病杂志, 1999, 17(3): 175-177 |
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| 作者姓名： | 李兴亮 李崇珍 车立刚 刘行知 李宗惠 黄德顺 何伟 刀清勇 |
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| 作者单位： | 云南省疟疾防治研究所!思茅6650002(李兴亮，李崇珍，车立刚，刘行知，李宗惠)，勐腊农场卫生科!勐腊6663003(黄德顺)，勐腊农场六分场卫生所!勐腊666300(何伟，刀清勇) |
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| 基金项目： | W H O／ TDR资助 |
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| 摘 要： | 目的： 观察复方蒿甲醚片治疗间日疟疗效的影响。方法：用复方蒿甲醚片（每片含苯芴醇 １２０ ｍ ｇ、蒿甲醚 ２０ ｍ ｇ）１６ 片３ ｄ 分服（ Ａ 组）、２０ 片５ ｄ 分服（ Ｂ组），氯喹 伯氨喹８ 日疗法（ Ｃ对照组）三组分别治疗３６ 例、４１ 例和 ５５ 例。结果： Ａ、 Ｂ、 Ｃ三组的平均退热时间相近，分别为 ２２．３ ｈ、２３．２ ｈ 和２５．０ ｈ；平均原虫转阴时间为３３．５ ｈ、３０．５ ｈ 和４４．９ ｈ； Ａ、 Ｂ两组均显著快于 Ｃ组（ Ｐ＜ ０．０１）。治后９ 个月的临床复发率： Ａ、 Ｂ、 Ｃ组各为８４．９％ 、７８．８％和 ２２．９％ ； Ａ、 Ｂ组均显著高于 Ｃ组（ Ｐ均＜ ０／０１）。结论：两种治疗方案治疗间日疟均具有速效。
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| 关 键 词： | 复方蒿甲醚 间日疟 临床疗效 复发 |
OBSERVATION ON EFFICACY OF ARTEMETHER COMPOUND AGAINST VIVAX MALARIA |
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| LI Xingliang,LI Chongzhen,CHE Ligang,LIU Xingzhi LI Zonghui,HUANG Deshun,HE Wei,DAO Qingyang. OBSERVATION ON EFFICACY OF ARTEMETHER COMPOUND AGAINST VIVAX MALARIA[J]. Chinese Journal of Parasitology and Parasitic Diseases, 1999, 17(3): 175-177 |
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| Authors: | LI Xingliang LI Chongzhen CHE Ligang LIU Xingzhi LI Zonghui HUANG Deshun HE Wei DAO Qingyang |
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| Affiliation: | Institute of Malaria Prevention and Treatment of Yunnan Province, Simao 665000. |
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| Abstract: | AIM: To observe the efficacy of artemether compound against vivax malaria. METHODS: Each artemether compound tablet contains 120 mg benflumetolum and 20 mg artemether. 132 patients with vivax malaria were divided into 3 groups. Group A, 36 patients received 8 tablets as an initial dose, followed by 4 tablets daily for 2 days; group B, 41 patients received 8 tablets as an initial dose, followed by 3 tablets daily for 4 days; group C, 55 patients receiving chloroguine-primaquine served as control. Two patients of group A were voluntarily to be bitten by Anopheles dirus before and after medication to observe the influence of artemether compound on the sporogony. RESULTS: The average defervescence times for groups A, B and C were 22.3 h, 23.2 h and 25.0 h (P > 0.05), respectively, the average parasite clearance times were 33.5 h, 30.5 h and 44.9 h, respectively, the average parasite clearance times of groups A and B were all significantly shorter than that of group C (P < 0.01). The replase rates of groups A, B and C were 84.9%, 78.8% and 22.9%, respectively, followed-up at nine months, the relapse rates of groups A and B were higher than that of group C(P < 0.01). CONCLUSION: Two regimens of artemether compound have the advantage of high efficacy against vivax malaria. |
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| Keywords: | Artemether compound vivax malaria efficacy relapse |
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