Serum inflammatory mediators correlate with disease activity in electrical status epilepticus in sleep (ESES) syndrome |
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| Authors: | Kees P. J. Braun H. Myrthe Boss Michèl A. Willemsen Annet van Royen‐Kerkhof Floor E. Jansen |
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| Affiliation: | 1. Department of Pediatric Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands;2. Department of Pediatric Neurology, Radboud University Medical Center, Nijmegen, The Netherlands;3. Department of Pediatric Immunology, Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands |
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| Abstract: | We aimed to study serum cytokine levels in 11 electrical status epilepticus in sleep (ESES) patients and 20 healthy control children. Patients showed significantly higher levels of interleukin (IL)‐1α, IL‐6, IL‐10, chemokine (C‐C motif) ligand (CCL)2 and chemokine (C‐X‐C motif) ligand (CXCL)8/IL‐8 than controls, while macrophage migration inhibitory factor (MIF) and CCL3 were significantly lower. Follow‐up analyses in five patients revealed a significant decrease of IL‐6 levels after immunomodulating treatment. IL‐6 changes were accompanied by clear improvement of electroencephalography (EEG) patterns and neuropsychological evaluation. We hypothesize that IL‐6 correlates with disease activity and immunomodulating treatment efficacy. |
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| Keywords: | Cytokines Electrical status epilepticus during sleep
ESES
Continuous spikes and waves during sleep
CSWS
Landau‐Kleffner syndrome |
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