Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis |
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| Authors: | Zwijnenburg Petra J G van der Poll Tom Florquin Sandrine Roord John J van Furth A Marceline |
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| Affiliation: | Department of Pediatrics, Vrije Universiteit Medical Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. p.j.zwijnenburg@amc.uva.nl |
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| Abstract: | To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced. |
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