| 先天性甲状腺功能减低症替代治疗骨密度值变化的研究 |
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| 引用本文： | 邵勤,李江英,汪时华. 先天性甲状腺功能减低症替代治疗骨密度值变化的研究[J]. 中国儿童保健杂志, 2012, 20(2): 161-163 |
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| 作者姓名： | 邵勤 李江英 汪时华 |
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| 作者单位： | 江西省妇幼保健院,江西 南昌 330006 |
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| 摘 要： | 【目的】 观察经新生儿疾病筛查程序诊治的先天性甲状腺功能减低症(congential hypothyroidism,CH)患儿骨密度状况,分析疾病本身及治疗因素对骨密度的影响。【方法】 以1~2岁CH患儿30例为研究对象,检测骨密度值,与正常儿童比较,并分析其影响因素。【结果】 CH组骨密度与正常对照组比较差异无统计学意义,与甲状腺组织发育情况及诊断时血清游离甲状腺素(free unbound thyroxin,FT4)水平有相关性。【结论】 CH患儿治疗后骨密度可达正常水平,甲状腺组织发育情况及诊断时FT4水平是影响骨密度的重要因素。
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| 关 键 词： | 先天性甲状腺功能减低症 骨密度 儿童 |
| 收稿时间： | 2011-10-09 |
Analysis of the bone mineral density and influencing factors in children with congential hypothyroidism treated with L-thyroxine |
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| SHAO Qin , LI Jiang-ying , WANG Shi-hua. Analysis of the bone mineral density and influencing factors in children with congential hypothyroidism treated with L-thyroxine[J]. Chinese Journal of Child Health Care, 2012, 20(2): 161-163 |
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| Authors: | SHAO Qin LI Jiang-ying WANG Shi-hua |
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| Affiliation: | Maternal and Child Health Care Hospital of Jiangxi,Nanchang,Jiangxi 330006,China |
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| Abstract: | 【Objective】 To observe the bone mineral density(BMD) in children with congential hypothyroidism(CH) detected by neonatal screening program and analyze the effects of the disease itself or therapy factors on BMD.【Method】 BMD was measured in 30 young children(1~2 years old) with CH and 68 normal children controls.【Results】 There was no significant difference between the patients and controls for BMD.The BMD of the CH patients had significant correlation with the severity of thyroid gland hypoplasia and FT4 level at the time of CH were diagnosed.【Conclusions】 The BMD of the children with CH are with the normal range.The severity of thyroid gland hypoplasia and FT4 level at the time of CH diagnosed have significant effects on BMD. |
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| Keywords: | congential hypothyroidism bone mineral density children |
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