| Oct-4在胃癌组织中的表达及临床意义 |
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| 引用本文： | 秦薇,张晓伟,章莉,张凤春. Oct-4在胃癌组织中的表达及临床意义[J]. 上海交通大学学报(医学版), 2009, 29(6) |
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| 作者姓名： | 秦薇 张晓伟 章莉 张凤春 |
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| 作者单位： | [1]上海交通大学医学院仁济医院肿瘤内科,上海200001 [2]上海交通大学新华医院肿瘤科,上海200092 |
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| 摘 要： | 目的研究干细胞相关标志物Oct-4在胃癌组织中的表达及临床意义。方法收集1996年6月-2006年3月胃癌手术石蜡标本63例，免疫组化法检测组织中Oct-4表达，分别以58例癌旁正常组织和10例正常胃黏膜组织标本作为对照。回顾63例患者的临床病理学指标，并分析各项指标与Oct-4表达的关系。对63例中的50例患者进行为期8年的生存随访，Kaplan—Meier法和Log-rank检验分析Oct-4表达与患者生存的关系；构建Cox回归模型，评估Oct-4作为胃癌患者预后的独立影响因素的可能性。结果Oct-4在胃癌组织中阳性表达率为80．95％（51／63），显著高于癌旁正常组织的5．2％（3／58）和正常胃黏膜组织（0）（P〈0．01）。Oct-4表达的阳性程度与胃癌的临床分期呈正相关（P〈0．01）。Oct-4表达在不同分化程度胃癌组织及不同年龄和性别患者间比较，差异无统计学意义（P〉0．05）。Oct-4表达阳性程度高的患者生存时间明显短于Oct-4表达阳性程度低的患者（P〈0．05）。Oct-4表达水平与胃癌患者预后无明显相关性（RR0．554，95％C10．209～1．466）。结论Oct-4在胃癌组织中表达的阳性程度与肿瘤临床分期及患者生存期有关，但不是胃癌患者预后的独立影响因素。
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| 关 键 词： | Oct-4 临床分期 生存期 预后 胃癌 |
Expression of Oct-4 in gastric carcinoma and its clinical significance |
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| QIN Wei,ZHANG Xiao-wei,ZHANG Li,ZHANG Feng-chun. Expression of Oct-4 in gastric carcinoma and its clinical significance[J]. Journal of Shanghai Jiaotong University:Medical Science, 2009, 29(6) |
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| Authors: | QIN Wei ZHANG Xiao-wei ZHANG Li ZHANG Feng-chun |
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| Affiliation: | 1.Department of Oncology;Renji Hospital;School of Medicine;Shanghai Jiaotong University;Shanghai 200001;China;2.Department of Oncology;Xinhua Hospital;Shanghai 200092;China |
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| Abstract: | Objective To investigate the expression of Oct-4 as a stem cell marker in gastric carcinoma tissues and its clinical significance.Methods From June 1996 to March 2006,63 paraffin samples of gastric carcinoma tissues were obtained,and the expression of Oct-4 was examined by immunohistochemical staining.Another 58 normal tissues adjacent to gastric carcinoma and 10 normal gastric mucosa tissues were served as controls.The clinicopathological data of 63 patients with gastric carcinoma were retrospectively anal... |
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| Keywords: | Oct-4 Oct-4 clinical stage survival time prognosis gastric carcinoma |
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