| SPF级大鼠自发性乳腺肿瘤的流行病学与病理学特点 |
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| 引用本文： | 赵磊,谷长勤,张万坡,张金明,杨文祥,张道宏,唐利军. SPF级大鼠自发性乳腺肿瘤的流行病学与病理学特点[J]. 实验动物与比较医学, 2007, 27(2): 116-119 |
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| 作者姓名： | 赵磊 谷长勤 张万坡 张金明 杨文祥 张道宏 唐利军 |
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| 作者单位： | 广东省实验动物监测所,广州,510260 |
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| 摘 要： | 目的ICR小鼠感染近平滑念珠菌试验前注射环磷酰胺,观察环磷酰胺对近平滑念珠菌感染ICR小鼠白细胞的影响。方法尾静脉注射近平滑念珠菌感染动物前,连续腹腔注射环林酰胺3次,同时设环磷酰胺组、近平滑念珠菌组和生理盐水组。每天采集血样,对动物血液白细胞进行分类计数。结果近平滑念珠菌组:6～7d白细胞高于正常水平,8d恢复正常水平;环磷酰胺组:1～6d白细胞数低于正常水平(第4天最低),7～10d高于正常水平(第9天最高),11～13、15、20d白细胞恢复正常水平;环磷酰胺作用后近平滑念珠菌感染组:1～6d白细胞变化趋势同环磷酰胺组,在7～11d白细胞呈上升趋势,并显著高于正常值,动物全部死亡。结论环磷酰胺能够在一定的时间段能有效降低ICR小鼠白细胞数,导致免疫功能低下。在近平滑念珠菌感染小鼠实验中得以充分利用。
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| 关 键 词： | 白细胞 近平滑念珠菌 环磷酰胺 ICR小鼠 |
| 文章编号： | 1004-8448（2007）02-0116-03 |
| 修稿时间： | 2006-08-24 |
Epidemiologic and Pathologic Characterization of Spontaneous Breast Tumors in SPF Rats |
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| ZHAO Lei,GU Chang-qin,ZHANG Wan-po,ZHANG Jin-ming,YANG Wen-xiang,ZHANG Dao-hong,TANG Li-jun. Epidemiologic and Pathologic Characterization of Spontaneous Breast Tumors in SPF Rats[J]. Laboratory Animal and Comparative Medicine, 2007, 27(2): 116-119 |
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| Authors: | ZHAO Lei GU Chang-qin ZHANG Wan-po ZHANG Jin-ming YANG Wen-xiang ZHANG Dao-hong TANG Li-jun |
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| Affiliation: | Guangdong Laboratory Animal Monitoring Institute, Guangzhou 510260, China |
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| Abstract: | Objective To investigate the effect of Cyclophosphamide on the white blood cell of C. parapsilosis infectted mouse. Methods ICR mouse were given cyclophosphamide once a day for 3 days before C.parapsilosis inoculation .The other mouse were injected with C.parapsilosis, cyclophos- phamide and N.S respectively as control groups. Then the mouse blood was collected and the blood were analysised. Results After C.parapsilosis inoculation, Cyclophosphamide treatment resulted in an imme- diate depression of peripheral blood leucocytes, with WBC and lymphocyte rebounding quickly to normal and rising throughtout the 2-week observation period, while mouse not treated with cyclophosphamide did not. And the cyclophosphamide model mouse, the number of WBC down quickly after inoculation , while up on the 5 day and recover to normal on the 11 day. Conclusion The WBC can be depressed effectively in some times with Cyclophosphamide; Cyclophosphamide can result in immunosuppression and play an important part in C.parapsilosis murine model. |
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| Keywords: | Leukocyte C.parapsilosis Cyclophosphamide ICR mouse |
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