| 112 例套细胞淋巴瘤临床病理分析* |
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| 引用本文： | 周冬梅, 陈 刚, 郑雄伟, 朱伟峰, 陈宝珍. 112 例套细胞淋巴瘤临床病理分析*[J]. 中国肿瘤临床, 2015, 42(2): 82-86. DOI: 10.3969/j.issn.1000-8179.20141779 |
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| 作者姓名： | 周冬梅 陈刚 郑雄伟 朱伟峰 陈宝珍 |
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| 作者单位： | 作者单位:福建省肿瘤医院病理科,福建省肿瘤医学转化重点实验室(福州市350014) |
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| 基金项目： | 本文课题受国家临床重点专科建设项目、福建省自然基金资助项目，福建省创新基金资助项目 |
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| 摘 要： | 目的：探讨套细胞淋巴瘤（mantle cell lymphoma，MCL ）的临床病理特点。方法：收集112 例MCL 的临床及病理资料，采用免疫组织化学（Envision二步法）行相关抗体标记，荧光原位杂交技术（fluorescence in situ hybridization，FISH）对其中24例作IgH/CCND1 基因断裂检测。结果：112 例（包括2 例多形性和母细胞变亚型）均表达B 细胞相关抗原，94.6%（106/112）表达cyclinD1，92.9%（104/112）表达CD5。不同免疫表型的经典型MCL 的Ki-67及平均生存期无统计学差异（P>0.05）。 3 例CD5-的MCL未检测出IgH/CCND1 基因断裂，2 例经典型MCL 检测出IgH/CCND1 多倍体。结论：MCL 是一种具有特殊免疫表型的B 细胞淋巴瘤，多形性及母细胞变异型的预后较差，对特殊亚型的MCL 诊断有必要细分。
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| 关 键 词： | 套细胞淋巴瘤 免疫组化 荧光原位杂交 预后 |
| 收稿时间： | 2014-10-23 |
| 修稿时间： | 2014-12-25 |
Clinicopathologic features of 112 patients with mantle cell lymphoma |
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| Dongmei ZHOU, Gang CHEN, Xiongwei ZHENG, Weifeng ZHU, Baozhen CHEN. Clinicopathologic features of112 patients with mantle cell lymphoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(2): 82-86. DOI: 10.3969/j.issn.1000-8179.20141779 |
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| Authors: | Dongmei ZHOU Gang CHEN Xiongwei ZHENG Weifeng ZHU Baozhen CHEN |
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| Affiliation: | Department of Pathology, Key Laboratory of Cancer Translational Medicine of Fujian, Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China. |
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| Abstract: | Objective:To explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL). Methods:Da-ta from 112 MCL cases were collected, and immunohistochemical assay was conducted. A break in the CCND1 gene was detected by fluorescence in situ hybridization (FISH). The t-test was used in the statistical analysis. Results: All tumor cells in the 112 cases ex-pressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all the cases, 106 expressed CD 5 and 104 expressed cyclinD1. A break in the CCND 1 gene was not found in 3 cases with CD 5-MCL. IgH/CCND 1 polyploid was found in 2 classical cases.Conclusion:MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis. |
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| Keywords: | mantle cell lymphoma immunohistochemistry fluorescence in situ hybridization prognosis |
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