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| 高血压病患者血浆降钙素基因相关肽和内皮素浓度的变化 | |
| 引用本文： | 叶季鲜,李红梅,黄静,杨春姣,李敏. 高血压病患者血浆降钙素基因相关肽和内皮素浓度的变化[J]. 心脏杂志, 2001, 13(3): 188-189,192. DOI: 10.13191/j.chj.2001.03.26.yejx.009 |
| 作者姓名： | 叶季鲜 李红梅 黄静 杨春姣 李敏 |
| 作者单位： | 1. 解放军第323医院心内科 2. 解放军第323医院中西科 3. 检验科, |
| 摘 要： | 目的 :探讨血浆降钙素基因相关肽 （CGRP）和内皮素 （ET）与高血压病之间关系。方法 :放射免疫方法检测 2 5例正常人和 36例高血压病患者降压治疗前后血浆 CGRP和 ET浓度 ,同时测量高血压病患者血压。结果 :1高血压病患者血浆 CGRP浓度低于正常人 ,与平均动脉压呈负相关 ;ET浓度高于正常人 ,与平均动脉压呈正相关。2有效降压治疗后 ,高血压病患者血浆 CGRP浓度回升 ,ET浓度下降 ,CGRP/ ET比值明显升高。结论 :血浆 CGRP和ET浓度失衡可能是高血压病发生的重要原因之一 ;有效降血压可能与 CGRP和 ET的变化有关。 |
| 关 键 词： | 高血压 降钙素 基因相关肽 内皮素 |
| 文章编号： | 1009-7236(2001)03-0188-02 |
Changes in plasmacalcitonin gene-related peptide and endothelin concentration in patients with essentialhypertension |
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| YE Ji xian ,LI Hong mei ,HUANG Jing ,YANG Chun jiao ,LI Min. Changes in plasmacalcitonin gene-related peptide and endothelin concentration in patients with essentialhypertension[J]. Chinese Heart Journal, 2001, 13(3): 188-189,192. DOI: 10.13191/j.chj.2001.03.26.yejx.009 | |
| Authors: | YE Ji xian LI Hong mei HUANG Jing YANG Chun jiao LI Min |
| Affiliation: | YE Ji xian 1,LI Hong mei 1,HUANG Jing 2,YANG Chun jiao 1,LI Min 3 |
| Abstract: | AIM:To investingate the relationship between the plasma cal citonin gene-related peptide (CGRP),endothelin (ET) in patient with essential hypertension. METHODS:We determined the plasma concentration of CGRP and ET in 25 no rmotension people and 36 patients with essential hypertension before and after a nti-hypertension treatment with radioimmunoassay,and measured the blood pressur e of essential hypertension patients. RESULTS:①The plasma CGRP concent ration in patients with essential hypertension was lower than that in the normot ension people,and there was a negative relationship between it and the mean arte ry pressure. The plasma ET concentration in patients with essential hypertension was higher than that in the normotension people, and there was a positive relat io nship between it and the mean artery pressure. ②After effective antihypertensio n treatment,the plasma CGRP concentration in the hypertensive was elevated,the p lasma ET concentration was lowered,and the rate of CGRP/ET was elevated. C ONCLUSION:The unbalance between plasma CGRP and ET concentration might be an important reason for essential hypertension,and the effective antihypertension treatment might regulate the balance between this pair of vasoactive substances . |
| Keywords: | hypertension calcitonin gene related peptide endothelin |
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