| 依西美坦和阿那曲唑在乳腺癌内分泌治疗中不良反应差异的分析 |
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| 引用本文： | 李 娜,杜扬帆,李 凯,闫顺朝. 依西美坦和阿那曲唑在乳腺癌内分泌治疗中不良反应差异的分析[J]. 现代肿瘤医学, 2019, 0(4): 574-579. DOI: 10.3969/j.issn.1672-4992.2019.04.008 |
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| 作者姓名： | 李 娜 杜扬帆 李 凯 闫顺朝 |
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| 作者单位： | 中国医科大学附属盛京医院肿瘤科，辽宁 沈阳 110022 |
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| 基金项目： | National Natural Science Foundation of China(No.81302313);国家自然科学基金项目（编号:81302313）;辽宁省自然科学基金指导计划（编号:20170540995）;沈阳市中青年科技创新人才支持计划项目（编号:RC170545） |
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| 摘 要： | 目的:探讨乳腺癌患者常用非甾体类芳香化酶抑制剂阿那曲唑和甾体类芳香化酶抑制剂依西美坦在不良反应方面的差异。方法:检索Pub Med、中国知识资源总库、CNKI、万方数据库中提供依西美坦和阿那曲唑不良反应的随机对照临床试验,对符合标准的文献提取相关不良反应指标,应用Rev Man 5. 3软件进行Meta分析。结果:纳入5项研究,荟萃分析结果显示阿那曲唑和依西美坦在导致潮热、乏力、高血压、关节炎或关节痛方面无显著差异,而应用依西美坦高甘油三酯血症的发生率比阿那曲唑少19%(OR=0. 81,95%CI:0. 69～0. 94; P=0. 005),高胆固醇血症的发生率比阿那曲唑少1 7%(OR=0. 83,95%CI:0. 76～0. 92; P=0. 000 3),差异有统计学意义。结论:依西美坦比阿那曲唑较少引起高甘油三酯血症和高胆固醇血症,对于有高甘油三酯血症或高胆固醇血症患者及其他心血管疾病高危因素的患者,依西美坦可能是更好的选择。
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| 关 键 词： | 阿那曲唑 依西美坦 内分泌治疗 不良反应 |
The difference of side-effects between exemestane and anastrozole in endocrine therapy of breast cancer |
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| Li Na,Du Yangfan,Li Kai,Yan Shunchao. The difference of side-effects between exemestane and anastrozole in endocrine therapy of breast cancer[J]. Journal of Modern Oncology, 2019, 0(4): 574-579. DOI: 10.3969/j.issn.1672-4992.2019.04.008 |
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| Authors: | Li Na Du Yangfan Li Kai Yan Shunchao |
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| Affiliation: | Department of Oncology,Shengjing Hospital of China Medical University,Liaoning Shenyang 110022,China. |
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| Abstract: | Objective:To explore the difference of side effects between nonsteroidal aromatase inhibitor anastrozole and steroidal aromatase inhibitor exemestane in breast cancer patients.Methods:Randomized controlled trials including side effects of exemestane and anastrozole were retrieved in the databases such as PubMed,Chinese knowledge resource pool,CNKI and Wanfang.RevMan 5.3 was used for Meta-analysis.Results:There are five studies were included.Meta-analysis results showed that there was no significant difference between anastrozole and exemestane in hot flashes,anemic,hypertension,and arthritis/joint pain.In hypertriglyceridemia,exemestane was nineteen percent lower than that of anastrozole (OR=0.81,95％CI:0.69~0.94,P=0.005),the difference was statistically significant.In hypercholesterolemia,exemestane was seventeen percent lower than that of anastrozole (OR=0.83,95%CI:0.76~0.92,P=0.000 3),the difference was statistically significant.Conclusion:Exemestane had less side effect than anastrozole in hypertriglyceridemia and hypercholesterolemia.Exemestane maybe a better choice for the patients who have high cholesterol,high triglyceride or other risk factors for cardiovascular disease. |
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| Keywords: | anastrozole exemestane endocrine therapy side effects |
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