| 水通道蛋白AQP4对乳腺癌细胞增殖的影响及机制 |
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| 引用本文： | 李英彬1,孙圣荣2. 水通道蛋白AQP4对乳腺癌细胞增殖的影响及机制[J]. 现代肿瘤医学, 2019, 0(6): 943-946. DOI: 10.3969/j.issn.1672-4992.2019.06.009 |
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| 作者姓名： | 李英彬1 孙圣荣2 |
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| 作者单位： | 1.内蒙古自治区人民医院，内蒙古 呼和浩特 010017;2.武汉大学人民医院，湖北 武汉 430060 |
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| 基金项目： | 内蒙古自治区人民医院院内基金（编号:2016032） |
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| 摘 要： | 目的:研究AQP4在人乳腺癌细胞中的表达，并进一步探讨AQP4对肿瘤细胞增殖的影响及机制。方法:通过 siRNA干扰技术下调乳腺癌细胞T47D 和 MCF-7 细胞系中水通道蛋白4表达，检测这种下调对乳腺癌细胞增殖的影响并初步探讨其作用机制。结果:AQP4表达下降抑制乳腺癌细胞的增殖，可能通过ERK通路/E-钙黏蛋白实现的。结论:AQP4表达水平与乳腺癌细胞增殖正相关，相应的肿瘤抑制剂可以起到控制肿瘤生长作用。
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| 关 键 词： | 水通道蛋白4 小干扰RNA 增殖 通路 |
Effect and mechanism of aquaporin AQP4 on proliferation of breast cancer cells |
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| Li Yingbin1,Sun Shengrong2. Effect and mechanism of aquaporin AQP4 on proliferation of breast cancer cells[J]. Journal of Modern Oncology, 2019, 0(6): 943-946. DOI: 10.3969/j.issn.1672-4992.2019.06.009 |
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| Authors: | Li Yingbin1 Sun Shengrong2 |
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| Affiliation: | 1.Inner Mongolia People's Hospital,Inner Mongolia Hohhot 010017,China；2.Renmin Hospital of Wuhan University,Hubei Wuhan 430060,China. |
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| Abstract: | Objective:To study the expression of AQP4 in human breast cancer cells,and further explore the effect and mechanism of AQP4 on the proliferation of tumor cells.Methods:Down regulation of aquaporin 4 expression in breast cancer cell lines T47D and MCF-7 was performed by siRNA interference technology.The effect of this downregulation on the proliferation of breast cancer cells was detected and its mechanism was explored.Results:The decrease of AQP4 expression inhibited the proliferation of breast cancer cells.It may be realized through the E-calcium/ERK pathway.Conclusion:AQP4 expression level is positively related to the proliferation of breast cancer cells.The corresponding tumor inhibitors can play a role in controlling tumor growth. |
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| Keywords: | aquaporin 4 small interfering RNA proliferation pathway |
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