Evidence from desensitization studies for distinct receptors for ATP and UTP on the rat superior cervical ganglion. |
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| Authors: | G. P. Connolly |
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| Affiliation: | Department of Physiology, University College London. |
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| Abstract: | Prolonged contact of the rat superior cervical ganglia (SCG) with the purine alpha,beta-methylene-ATP (alpha,beta-Me-ATP) selectively depressed responses to ATP and alpha,beta-Me-ATP but not responses to uridine 5'-triphosphate (UTP), potassium or adenosine. Prolonged contact with the pyrimidine UTP selectively depressed responses to UTP but not responses evoked by alpha,beta-Me-ATP, potassium or adenosine. These results are consistent with the presence of P2-purinoceptors and pyrimidinoceptors on the rat SCG and the hypothesis that pyrimidinoceptors exist within the nervous system. |
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