| 肿瘤休眠与血管新生 |
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| 引用本文： | 张瑜, 车国卫. 肿瘤休眠与血管新生[J]. 中国肿瘤临床, 2008, 35(5): 293-296. |
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| 作者姓名： | 张瑜 车国卫 |
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| 作者单位： | 四川大学华西医院胸心外科, 成都市 610041 |
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| 基金项目： | 本文课题受国家自然科学基金资助(编号:30400199) |
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| 摘 要： | 肿瘤休眠是指肿瘤细胞在宿主体内持续存在而没有明显生长的一种状态,存在复发和转移的可能性,是恶性肿瘤难以彻底根治的根源之一。现在研究表明血管新生与肿瘤演进密切相关。本文从血管新生与肿瘤休眠的关系,肿瘤休眠模型的建立,肿瘤休眠的研究方法,休眠标志物的检测等方面进行了论述。旨在为阐明血管生成与肿瘤休眠的关系,以及临床应用抗血管生成疗法治疗肿瘤提供有益的线索。
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| 关 键 词： | 肿瘤休眠 血管新生表型 肿瘤休眠疗法 |
| 收稿时间： | 2007-04-23 |
| 修稿时间： | 2007-04-23 |
Recent Advances in Our Understanding of Angiogenesis and Tumor Dormancy |
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| ZHANG Yu, CHE Guo-wei. Recent Advances in Our Understanding of Angiogenesis and Tumor Dormancy[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2008, 35(5): 293-296. |
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| Authors: | ZHANG Yu CHE Guowei |
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| Affiliation: | Department of Cardiovascular Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China |
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| Abstract: | Tumor dormancy, a complex and still poorly understood phenomenon observed both in experimentalmodels and in patients, has been defined by the long-term persistence of occult cancer cells during tumor progression.Recurrence and metastasis may occur because of this small population of tumor cells. Sustained angiogenesis is consideredessential in triggering invasive tumor growth. Here we discuss the correlation between angiogenesis and tumor dormancy,the establishment of tumor dormancy models and new biomarkers for detecting microscopic tumors before or during the an-giogenic switch. The imaging techniques and the different strategies for isolation of both angiogenic and non-angiogenictumor cell populations are also summarized. To eradicate dormant disease, it is imperative to understand the role of angio-genesis in tumor dormancy. |
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| Keywords: | Tumor dormancy Angiogenic phenotype Tumor dormancy therapy |
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