Deletion of the multiple-drug efflux pump AcrAB in Escherichia coli prolongs the postantibiotic effect |
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| Authors: | Stubbings William Bostock Julieanne Ingham Eileen Chopra Ian |
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| Affiliation: | Antimicrobial Research Centre and School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK. |
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| Abstract: | The mechanism of the postantibiotic effect (PAE) was examined in Escherichia coli. Drugs exhibited longer-lasting PAEs in an acrAB mutant, suggesting that intracellular drug concentrations influence the duration of the PAE. With specific assays for tetracycline and erythromycin, a direct link between intracellular persistence of antibiotics and maintenance of the PAE was established. |
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