Transplant center volume and outcomes in lung transplantation for cystic fibrosis |
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| Authors: | Don Hayes Jr. Stuart C. Sweet Christian Benden Benjamin T. Kopp Samuel B. Goldfarb Gary A. Visner George B. Mallory Joseph D. Tobias Dmitry Tumin |
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| Affiliation: | 1. Department of Pediatrics, The Ohio State University, Columbus, OH, USA;2. Department of Internal Medicine, The Ohio State University, Columbus, OH, USA;3. Department of Surgery, The Ohio State University, Columbus, OH, USA;4. Center for Epidemiology of Organ Failure and Transplantation, Nationwide Children's Hospital, Columbus, OH, USA;5. Section of Pulmonary Medicine, Nationwide Children's Hospital, Columbus, OH, USA;6. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA;7. Department of Pediatrics, Pereleman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA;8. Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA;9. Department of Pediatrics, Harvard Medical School, Boston, MA, USA;10. Division of Pulmonary and Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA;11. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA;12. Division of Pulmonary Medicine, Texas Children's Hospital, Houston, TX, USA;13. Department of Anesthesiology, The Ohio State University, Columbus, OH, USA;14. Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA |
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| Abstract: | Transplant volume represents lung transplant (LTx) expertise and predicts outcomes, so we sought to determine outcomes related to center volumes in cystic fibrosis (CF). United Network for Organ Sharing data were queried for patients with CF in the United States (US) receiving bilateral LTx from 2005 to 2015. Multivariable Cox regression was used to model survival to 1 year and long‐term (>1 year) survival, conditional on surviving at least 1 year. A total of 2025 patients and 67 centers were included in the analysis. The median annual LTx volumes were three in CF [interquartile range (IQR): 2, 6] and 17 in non‐CF (IQR: 8, 33). Multivariable Cox regression in cases with complete data and surviving at least 1 year (n = 1510) demonstrated that greater annual CF LTx volume (HR per 10 LTx = 0.66; 95% CI: 0.49, 0.89; P = 0.006) but not greater non‐CF LTx volume (HR = 1.00; 95% CI: 0.96, 1.05; P = 0.844) was associated with improved long‐term survival in LTx recipients with CF. A Wald interaction test confirmed that CF LTx volume was more strongly associated with long‐term outcomes than non‐CF LTx volume (P = 0.012). In a US cohort, center volume was not associated with 1‐year survival. CF‐specific expertise predicted improved long‐term outcomes of LTx for CF, whereas general LTx expertise was unassociated with CF patients’ survival. |
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| Keywords: | center volume cystic fibrosis lung transplantation survival |
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