The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerogenes |
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| Authors: | Pradel Elizabeth Pagès Jean-Marie |
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| Affiliation: | INSERM CJF9606-EA2197, IFR48, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France. elizabeth.pradel@medecine.univ-mrs.fr |
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| Abstract: | We identified the genes encoding the AcrA-AcrB-TolC efflux pump in Enterobacter aerogenes and constructed acrAB and tolC mutants from a multidrug-resistant isolate. Both derivatives were more susceptible to antibiotics than the parental strain. Sequence analysis and complementation experiments revealed that the multidrug-resistant isolate is an acrR mutant. |
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