| 肠出血性大肠埃希菌O157 ∶ H7质粒 pO157 上毒力因子的研究进展 |
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| 引用本文： | 张晓嫒,叶长芸,徐建国. 肠出血性大肠埃希菌O157 ∶ H7质粒 pO157 上毒力因子的研究进展[J]. 疾病监测, 2011, 26(6): 479-483. DOI: 10.3784/j.issn.1003-9961.2011.06.017 |
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| 作者姓名： | 张晓嫒 叶长芸 徐建国 |
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| 作者单位： | 1.中国疾病预防控制中心传染病预防控制所 传染病预防控制国家重点实验室,北京 102206 |
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| 摘 要： | 肠出血性大肠埃希菌O157 ∶ H7是一种重要的致病菌,可以引起不同程度人类疾病。目前已知的O157 ∶ H7的致病因子有3个,志贺毒素、粘附抹平效应毒力岛和特异性质粒pO157。其中pO157在致病过程中的作用并不十分清楚。本文结合近年来的研究进展,介绍了pO157上与细菌致病性有关的毒力因子。
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| 关 键 词： | 大肠埃希菌O157 ∶ H7 毒力因子 质粒 pO157 致病性 |
| 收稿时间： | 2011-02-25 |
Progress on research of virulence factors on plasmid pO157 of EHEC O157:H7 |
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| ZHANG Xiao-ai , YE Chang-yun , XU Jian-guo. Progress on research of virulence factors on plasmid pO157 of EHEC O157:H7[J]. Disease Surveillance, 2011, 26(6): 479-483. DOI: 10.3784/j.issn.1003-9961.2011.06.017 |
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| Authors: | ZHANG Xiao-ai YE Chang-yun XU Jian-guo |
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| Affiliation: | 1.State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing 102206, China |
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| Abstract: | Enterohemorrhagic Escherichia coli（EHEC） O157∶H7 is a major pathogen,which can cause severe disease in humans.Three major virulence factors of E.coli O157∶H7 have been identified including Shiga toxin,products of the pathogenicity island called locus of enterocyte effacement and products of F-like plasmid pO157.Among these virulence factors,the role of pO157 is less understood.This paper summarizes the research progress on virulence factor on pO157 of E.coli O157∶H7. |
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| Keywords: | Escherichia coli O157∶H7 virulence factor plasmid pO157 pathogenicity |
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