| 药物性肝损害临床流行病学研究进展 |
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| 引用本文： | 陈富琴陈章张俊然杨孝光罗涵任建东路强李运明. 药物性肝损害临床流行病学研究进展[J]. 药物流行病学杂志, 2016, 0(12): 810-818 |
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| 作者姓名： | 陈富琴陈章张俊然杨孝光罗涵任建东路强李运明 |
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| 作者单位： | ①成都军区总医院信息科（成都 610083）；②四川大学电气信息学院医学信息工程系；③成都军区总医院呼吸内科；④成都军区总医院药剂科 |
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| 基金项目： | 四川省科技计划项目（编号：2014JY0149）；医院研究型人才计划（编号：2013YG-B021） |
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| 摘 要： | 摘要 药物性肝损害是最常见的药品不良反应之一，重者会导致黄疸、急性肝功能衰竭甚至死亡。其发病率逐年上升，已越来越受到人们的关注。影响因素包括患者因素（如年龄、性别、妊娠、营养不良和基础疾病等）、药物因素和环境因素。有效利用医院信息系统开展监测预警药物性肝损害的发生至关重要，因此建议国家和政府尽快建立药物性肝损害的监测系统。
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| 关 键 词： | 药物性肝损害；危险因素；医院信息系统；监测系统 |
Advances in Clinical Epidemiology of Drug induced Liver Injury |
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| Chen Fuqin,Chen Zhang,Zhang Junran,Yang Xiaoguang,Luo Han,Ren Jiandong,Lu Qiang,Li Yunming. Advances in Clinical Epidemiology of Drug induced Liver Injury[J]. Chinese Journal of Pharmacoepidemiology, 2016, 0(12): 810-818 |
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| Authors: | Chen Fuqin Chen Zhang Zhang Junran Yang Xiaoguang Luo Han Ren Jiandong Lu Qiang Li Yunming |
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| Abstract: | ABSTRACTDrug induced liver injury was one of the most common adverse drug reactions, severe cases could lead to jaundice, acute liver failure and even death. Incidence of drug induced liver injury was increasing with year, and it had been paied more and more attention. Influence factors incuded host factors (such as age, sex, pregnancy, malnutrition and underlying diseases), drug and environmental factors. It was vital important to carry out monitoring and early warning drug induced liver injury using hospital information system effectively, so it was recommended that the government establish a national monitoring system for drug induced liver injury as soon as possible. |
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| Keywords: | Drug induced liver injury Influence factors Hospital information system Monitoring system |
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