Successful Treatment of Genetically Profiled Pediatric Extranodal NK/T‐Cell Lymphoma Targeting Oncogenic STAT3 Mutation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Successful Treatment of Genetically Profiled Pediatric Extranodal NK/T‐Cell Lymphoma Targeting Oncogenic STAT3 Mutation

Authors:	Troy A. McEachron PhD Ivan Kirov MD Minkkwan Wungwattana MD Daisy Cortes MD Keri B. Zabokrtsky MS Aaron Sassoon MD PhD David Craig PhD John D. Carpten PhD Leonard S. Sender MD

Affiliation:	1. Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, Arizona;2. Hyundai Cancer Genomics Center, Children's Hospital of Orange County, Orange, California;3. Division of Oncology, Hyundai Cancer Institute, Children's Hospital of Orange County, Orange, California;4. Pediatric Hematology/Oncology Residency Program, School of Medicine, University of California‐Irvine/Children's Hospital of Orange County, Orange, California;5. Pediatric Hematology/Oncology Fellowship Program, School of Medicine, University of California‐Irvine/Children's Hospital of Orange County, Orange, California;6. Division of Hematology‐Oncology, Department of Medicine, School of Medicine, University of California‐Irvine, Orange, California;7. Department of Pathology, Children's Hospital of Orange County, Orange, California;8. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona;9. Department of Pediatrics, School of Medicine, University of California‐Irvine, Orange, California

Abstract:	Extranodal natural killer (NK)/T‐cell lymphoma (ENKTCL) is a distinct type of non‐Hodgkin lymphoma predominantly observed in Asian and Latin American adult males. A 12‐year‐old Hispanic female diagnosed with ENKTCL was enrolled in our genomic profiling research protocol. We identified specific somatic alterations consistent with diagnosis of ENKTCL as well as oncogenic mutations in MAP2K1 and STAT3. To our knowledge, this is the first report of an immunophenotypically confirmed and genetically profiled case of ENKTCL in a female pediatric patient in the United States, including its unique treatment and favorable outcome.

Keywords:	extranodal NK/T‐cell lymphoma genome STAT3

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