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Novel cinnamic acid–tryptamine hybrids as potent butyrylcholinesterase inhibitors: Synthesis,biological evaluation,and docking study
Authors:Shahrzad Ghafary  Zahra Najafi  Maryam Mohammadi‐Khanaposhtani  Hamid Nadri  Najmeh Edraki  Neda Ayashi  Bagher Larijani  Mohsen Amini  Mohammad Mahdavi
Affiliation:1. Faculty of Pharmacy, Department of Medicinal Chemistry, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran;3. Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran;4. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran;5. Faculty of Pharmacy, Department of Medicinal Chemistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;6. Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;7. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;8. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
Abstract:
Keywords:Alzheimer's disease  butyrylcholinesterase inhibitors  cholinesterase inhibition  cinnamic acid  docking study  tryptamine
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