| 2013-2020年北京市海淀区成年人致泻大肠埃希菌流行特征和分型研究 |
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| 引用本文： | 白婧,施丽飞,韩喜荣. 2013-2020年北京市海淀区成年人致泻大肠埃希菌流行特征和分型研究[J]. 疾病监测, 2022, 37(1): 77-83. DOI: 10.3784/jbjc.202102260340 |
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| 作者姓名： | 白婧 施丽飞 韩喜荣 |
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| 作者单位： | 北京市海淀区疾病预防控制中心, 北京 100094 |
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| 摘 要： | 目的 掌握北京市海淀区成年人致泻大肠埃希菌(DEC)流行特征和脉冲场凝胶电泳(PFGE)分型特点.方法 对2013-2020年在3家哨点医院就诊的1961例成年人腹泻患者粪便或肛拭子标本进行DEC检测,对其中66株DEC菌株进行PFGE分型试验.结果 成年人DEC检出率为9.54％(187/1961),产肠毒素大肠埃希...
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| 关 键 词： | 致泻大肠埃希菌 脉冲场凝胶电泳 流行特征 成年人 分型 |
| 收稿时间： | 2021-02-26 |
Epidemiological characteristics and typing of diarrheagenic Escherichia coli from adults in Haidian district of Beijing,2013-2020 |
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| Bai Jing,Shi Lifei,Han Xirong. Epidemiological characteristics and typing of diarrheagenic Escherichia coli from adults in Haidian district of Beijing,2013-2020[J]. Disease Surveillance, 2022, 37(1): 77-83. DOI: 10.3784/jbjc.202102260340 |
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| Authors: | Bai Jing Shi Lifei Han Xirong |
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| Affiliation: | Beijing Haidian District Center for Disease Control and Prevention, Beijing 100094, China |
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| Abstract: | Objective To understand the epidemiological characteristics and pulsed-field gel electrophoresis (PFGE) typing of diarrheagenic Escherichia coli (DEC) isolated from adults in Haidian district of Beijing from 2013 to 2020. Methods Stool samples or anal swabs were collected from 1961 adults with diarrhea in 3 sentinel hospitals for DEC detection. Meanwhile, the 66 strains isolated were used for analyzed for genetic typing by PFGE. Results A total of 187 DEC strains we're detected from 1 961 cases (9.54%). Enterotoxigenic E. coli (ETEC) and enteroaggregative E. coli (EAEC) had higher detection rates of 4.18% (82/1 961) and 3.93% (77/1 961), respectively. The proportion of astA/pic in EAEC and estIa/estIb in ETEC were highest, accounting for 79.22% (61/77) and 84.15% (69/82), respectively. The gender, age and occupation specific differences in DEC detection rate showed no significance. The proportions of patients with fever, vomiting and abdominal pain were 28.65% (53/185), 34.59% (64/185) and 78.92% (146/185) respectively. The predominant types of DEC varied in different years, the detection rate of DEC was high during June–September. No same PFGE patterns or pattern clustering were found for EAEC and Enteropathogenic E. coli (EPEC). A total of 19 PFGE patterns were detected in 23 ETEC strains indicated by cluster analysis. The similarity between these patterns was 4.84%–100.0%. Conclusion The detection rate of DEC increased in recent years, and ETEC and EAEC were predominant. It is necessary to collect and analyze the information about the epidemiological characteristics of diarrhea patients and establish the local database of DEC PFGE pattern to provide reliable data supporting for the prevention and control of DEC infection in the future. |
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