In vitro activities of chloroquine in combination with chlorpromazine or prochlorperazine against isolates of Plasmodium falciparum. |
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| Authors: | L K Basco and J Le Bras |
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| Affiliation: | Centre National de Référence pour la Chimiosensibilité du Paludisme, H?pital Bichat-Claude Bernard, Paris, France. |
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| Abstract: | The combinations of chloroquine plus chlorpromazine and chloroquine plus prochlorperazine were evaluated in vitro for potentiation against isolates of Plasmodium falciparum. Potentiation was observed against all chloroquine-resistant isolates. There was no potentiation against 8 of 10 chloroquine-susceptible isolates. The results indicated that the phenothiazines can potentiate chloroquine action against resistant parasites found in natural conditions. |
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