Enhanced gamma interferon responses of mouse spleen cells following immunotherapy for tuberculosis relapse |
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| Authors: | Gil Olga Vilaplana Cristina Guirado Evelyn Díaz Jorge Cáceres Neus Singh Mahavir Cardona Pere-Joan |
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| Affiliation: | Olga Gil, Cristina Vilaplana, Evelyn Guirado, Jorge Díaz, Neus Cáceres, Mahavir Singh, and Pere-Joan Cardona |
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| Abstract: | Gamma interferon responses of spleen cells in mice were examined during postchemotherapy relapse of intraperitoneally induced latent tuberculous infection. The mycobacterial extract RUTI, which prevented the relapse, significantly enhanced the immune responses to secreted and structural recombinant mycobacterial antigens, suggesting that RUTI-mediated protection was mediated by activated T cells. |
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