| 月桂氮怠酮对■丙嗪透皮吸收作用的研究 |
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| 引用本文： | 潘旭初. 月桂氮怠酮对■丙嗪透皮吸收作用的研究[J]. 中国药学杂志, 1997, 0(1) |
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| 作者姓名： | 潘旭初 |
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| 作者单位： | 湖北省药学会 |
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| 摘 要： | 目的：考察月桂氮酮对丙嗪透皮作用的影响。方法：应用简单小室法，以蛇皮为透皮屏障，使用不同浓度的月桂氮酮，测量丙嗪的透皮吸收量。结果：含０．５％，１．０％，２．０％，３．０％月桂氮酮的丙嗪擦剂与不含月桂氮酮的丙嗪擦剂间，其透皮吸收有显著性（Ｐ＜０．０５）或极显著性差异（Ｐ＜０．０１），月桂氮酮对丙嗪的透皮吸收促进作用无浓度依赖性。结论：不同浓度的月桂氮酮均能明显促进丙嗪的透皮吸收，其中以含０．５％的月桂氮酮浓度，促丙嗪吸收效果最佳。
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| 关 键 词： | 月桂氮怠酮；透皮吸收 |
Azone affecting the transdermal absorption of oxaprozin |
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| Pan Xuchu. Azone affecting the transdermal absorption of oxaprozin[J]. Chinese Pharmaceutical Journal, 1997, 0(1) |
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| Authors: | Pan Xuchu |
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| Abstract: | OBJECTIVE:To observe the effects of Azone affecting the transdermal amount of oxaprozin.METHOD:Using simple cell method and snake skin as transdermal barrier,we determined the transdermal amount of oxaprozin in different Azone concentrations liniments.RESULTS:Comparison of oxaprozin liniment having no Azone with the liniments containing different Azone concentrations of 0.5%,1.0%,2.0%,3.0% showed a remarkable difference(P<0.05) or very remarkable difference(P<0.01).Improving the transdermal amount of oxaprozin was not related to the concentrations of Azone.CONCLUSION:All different concentrations of Azone could improve the transdermal amount of oxaprozin,especially,oxaprozin liniment containing 0.5% Azone. |
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| Keywords: | Azone oxaprozin transdermal absorption |
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