Cefaclor: In Vitro Spectrum of Activity and Beta-Lactamase Stability |
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| Authors: | Harold C. Neu and Kwung P. Fu |
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| Affiliation: | 1Departments of Medicine and Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York 10032 |
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| Abstract: | The in vitro activity of cefaclor against 556 clinical isolates of gram-positive and gram-negative bacteria was compared with that of other cephalosporins. Cefaclor had activity similar to that of cephalexin against gram-positive bacteria. It showed greater activity against Haemophilus strains than did cephalexin and inhibited β-lactamase-producing Haemophilus isolates. Cefaclor was more active than cephalexin or cephalothin against Escherichia coli, Salmonella, and Shigella isolates but did not act against Serratia, Acinetobacter, indole-positive Proteus, or Bacteroides isolates. Cefaclor was resistant to type III (TEM) β-lactamases but was destroyed by type I β-lactamases and, to a lesser degree, by type IV and type V β-lactamases. |
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