High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae |
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| Authors: | Wolter Nicole Smith Anthony M Low Donald E Klugman Keith P |
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| Affiliation: | Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Medical Research Council and University of the Witwatersrand, Johannesburg, South Africa. nicolew@nicd.ac.za |
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| Abstract: | A rare clinical isolate of Streptococcus pneumoniae, highly resistant to telithromycin, contained erm(B) with a truncated leader peptide and a mutant ribosomal protein L4. By transformation of susceptible strains, this study shows that high-level telithromycin resistance is conferred by erm(B), wild type or mutant, in combination with a (69)GTG(71)-to-TPS mutation in ribosomal protein L4. |
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