Selection of Streptococcus pneumoniae Mutants Having Reduced Susceptibility to Moxifloxacin and Levofloxacin |
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| Authors: | Xinying Li Xilin Zhao Karl Drlica |
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| Affiliation: | Public Health Research Institute, New York, New York 10016, USA. |
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| Abstract: | With Streptococcus pneumoniae, moxifloxacin was 4- and 10-fold more effective than levofloxacin at restricting selection of resistant mutants and at killing resistant mutants, respectively. The selection frequency for first-step topoisomerase mutants was 1,000 times lower for moxifloxacin than for levofloxacin; this difference was lost when second-step mutants were selected. |
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