Selective inhibition by vasocortin of histamine release induced by dextran and concanavalin-A from rat peritoneal cells |
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| Authors: | R Carnuccio M Di Rosa A Ialenti T Iuvone L Sautebin |
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| Affiliation: | Department of Experimental Pharmacology, University of Naples, Italy. |
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| Abstract: | Vasocortin, a glucocorticoid-induced anti-inflammatory protein, has been purified from the peritoneal lavage fluid of dexamethasone-treated rats. Vasocortin inhibited the release of histamine from rat peritoneal cells stimulated by dextran or concanavalin A but did not alter the release induced by calcium ionophore A23187 or compound 48/80. This selective effect exhibited by vasocortin mimics the glucocorticoid inhibition of histamine release from rat mast cells. |
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