| 微生物相关基因富集分析法鉴定风湿病相关肠道微生物群 |
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| 引用本文： | 何培, 王曼利, 曹蓉蓉, 董晨悦, 邓飞艳, 雷署丰. 微生物相关基因富集分析法鉴定风湿病相关肠道微生物群[J]. 中华疾病控制杂志, 2021, 25(8): 874-878,986. doi: 10.16462/j.cnki.zhjbkz.2021.08.002 |
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| 作者姓名： | 何培 王曼利 曹蓉蓉 董晨悦 邓飞艳 雷署丰 |
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| 作者单位： | 1.215123 苏州，苏州大学医学部公共卫生学院遗传流行病与基因组学中心;;2.332000 九江，九江市第一人民医院肾内科 |
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| 基金项目： | 国家自然科学基金81473046 |
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| 摘 要： | 目的 鉴定与类风湿关节炎(rheumatoid arthritis, RA)、系统性红斑狼疮(systemic lupus erythematosus, SLE)和强直性脊柱炎(ankylosing spondylitis, AS)相关的肠道微生物群。方法 利用已发表的全基因组关联研究(genome-wide association study, GWAS)和肠道微生物群GWAS的总结数据，运用肠道微生物群相关基因富集分析(gene set enrichment analysis, GSEA)方法检测肠道微生物群和风湿病之间的关联。结果 通过鉴定发现多个肠道微生物群均与三种风湿病相关(均有P＜0.05)。其中，瘤胃球菌属(Ruminococcaceae_UCG-009)与RA、SLE和AS均相关(均有P＜0.05)；Intestinibacter属和发酵性厌氧梭菌潜在新物种(Candidatus_Soleaferrea)则与RA和SLE相关(均有P＜0.05)。结论 部分肠道微生物群可能通过其代谢物的作用成为新的风湿病调节因子，这为揭示肠道微生物群在风湿病中的作用提供了新的线索。
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| 关 键 词： | 风湿病 肠道微生物 全基因组关联研究 肠道微生物群相关基因富集分析 |
| 收稿时间： | 2021-06-29 |
| 修稿时间： | 2021-07-16 |
Identifying rheumatoid diseases-associated gut microbiota using microbiota-related gene set enrichment analysis |
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| HE Pei, WANG Man-li, CAO Rong-rong, DONG Chen-yue, DENG Fei-yan, LEI Shu-feng. Identifying rheumatoid diseases-associated gut microbiota using microbiota-related gene set enrichment analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(8): 874-878,986. doi: 10.16462/j.cnki.zhjbkz.2021.08.002 |
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| Authors: | HE Pei WANG Man-li CAO Rong-rong DONG Chen-yue DENG Fei-yan LEI Shu-feng |
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| Affiliation: | 1. Center for Genetic Epidemiology and Genomics, School of Public Health, Medical College of Soochow University, Suzhou 215123, China;;2. Department of Nephrology, Jiujiang No.1 People's Hospital, Jiujiang 332000, China |
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| Abstract: | Objective This study aims to detect the association between gut microbiota and rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and ankylosing spondylitis (AS). Methods The microbiota-related gene set enrichment analysis (GSEA) was applied to identify rheumatoid diseases-related gut microbiota using published genome-wide association study (GWAS) and GWAS of gut microbiota summary statistic data. Results Several associations between three rheumatoid diseases and gut microbiota were identified (all P < 0.05). Thereinto, Ruminococcaceae_UCG-009 was significantly associated with RA, SLE and AS (all P < 0.05). For RA and SLE, association signals were observed for Intestinibacter and Candidatus_Soleaferrea (all P < 0.05). Conclusion This study found that part of the gut microbiota could be novel regulators of rheumatoid diseases via the effects of its metabolites, and may provide novel clues for revealing the roles of gut microbiota in rheumatology. |
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| Keywords: | Rheumatoid diseases Gut microbiota GWAS Microbiota-related GSEA |
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