| 人脑类器官在神经发育疾病研究中的应用 |
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| 引用本文： | 马燕燕,龚瑶琴. 人脑类器官在神经发育疾病研究中的应用[J]. 山东大学学报(医学版), 2021, 59(9): 22-29. DOI: 10.6040/j.issn.1671-7554.0.2021.0937 |
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| 作者姓名： | 马燕燕 龚瑶琴 |
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| 作者单位： | 山东大学基础医学院遗传学系 实验畸形学教育部重点实验室,山东 济南250012 |
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| 基金项目： | 国家自然科学基金(82171851) |
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| 摘 要： | 人脑类器官是由人多能干细胞(hPSC)包括人胚胎干细胞(hESC)和人诱导多功能干细胞(hiPSC)衍生而来的三维组织,能模拟人大脑的结构和功能,作为神经发育疾病的体外研究模型独具优势.本文将对神经疾病体外模型建立和发展的历程、脑类器官在神经发育疾病研究中的应用、相关前沿技术和脑类器官技术的结合等进行综述和展望.
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| 关 键 词： | 多能干细胞 脑类器官 神经发育疾病 单细胞RNA测序 |
Application of brain organoids in investigating neurodevelopmental diseases |
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| MA Yanyan,GONG Yaoqin. Application of brain organoids in investigating neurodevelopmental diseases[J]. Journal of Shandong University:Health Sciences, 2021, 59(9): 22-29. DOI: 10.6040/j.issn.1671-7554.0.2021.0937 |
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| Authors: | MA Yanyan GONG Yaoqin |
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| Affiliation: | Department of Genetics, School of Basic Medical Sciences, Shandong University, Key Laboratory of Experimental Teratology, Ministry of Education, Jinan 250012, Shandong, China |
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| Abstract: | Human brain organoids are self-assembled three-dimensional aggregates derived from human pluripotent stem cells(hPSCs), including embryonic stem cells(ESCs)and induced pluripotent stem cells(iPSCs). Brain organoids display the structures that resemble defined brain regions and simulate specific change of neurological disease, and have become an excellent model for investigating human neurodevelopmental diseases in vitro. In this paper, we will review the recent advances in the generation of brain organoids and the application of brain organoids in modeling major neurodevelopmental diseases, as well as the combination of cutting-edge technologies with brain organoids. |
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| Keywords: | Pluripotent stem cells Brain organoid Neurodevelopmental diseases Single-cell RNA sequencing |
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