| 卵巢癌耐药机制与靶向治疗策略的研究进展 |
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| 引用本文： | 哈春芳,李茹月. 卵巢癌耐药机制与靶向治疗策略的研究进展[J]. 山东大学学报(医学版), 2021, 59(9): 117-123. DOI: 10.6040/j.issn.1671-7554.0.2021.0956 |
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| 作者姓名： | 哈春芳 李茹月 |
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| 作者单位： | 宁夏医科大学总医院妇科,宁夏 银川750004;生育力保持教育部重点实验室,宁夏 银川750004;宁夏医科大学,宁夏 银川750004 |
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| 基金项目： | 宁夏重点研发项目(2019BFG02002) |
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| 摘 要： | 手术结合化疗是卵巢上皮性癌的主要治疗手段,其中以R0为目标的卵巢癌肿瘤细胞减灭术结合个体化的化疗方案的应用,使得部分患者5年生存率有了很大的提升.但是晚期患者的耐药与复发仍然是困扰广大临床医师与科研工作者的难题,而化疗耐药因其病因不清、机制复杂,是临床亟待解决的难题和热点.近年来围绕此问题开展的基础与临床相结合的卵巢癌...
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| 关 键 词： | 卵巢癌 耐药 机制 靶向治疗 |
Research progress of drug resistance in ovarian cancer and targeted therapy strategy |
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| HA Chunfang,LI Ruyue. Research progress of drug resistance in ovarian cancer and targeted therapy strategy[J]. Journal of Shandong University:Health Sciences, 2021, 59(9): 117-123. DOI: 10.6040/j.issn.1671-7554.0.2021.0956 |
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| Authors: | HA Chunfang LI Ruyue |
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| Affiliation: | 1. Gynecology Department, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China; 2. Key Laboratory of Fertility Preservation and Maintenance of Ministry of Education, Yinchuan 750004, Ningxia, China;3. Ningxia Medical University, Yinchuan 750004, Ningxia, China |
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| Abstract: | Cytoreductive surgery combined with chemotherapy is the major treatment of Epithelial ovarian cancer(EOC). The application of no residual disease(R0)targeted ovarian cancer debulking with individualized chemotherapy has greatly improved the five-year survival rates. However, the drug resistance and recurrence of advanced patients are still a difficult problem for clinicians and researchers in this field. Chemotherapy resistance is a hot and difficult spot to be solved urgently due to unclear etiology and complex mechanism. In recent years, the basic and clinical researches on the mechanism of drug resistance in ovarian cancer mainly include drug transport, drug metabolism, apoptosis, DNA damage repair and epigenetic changes. And some studies have shown that autophagy, altered metabolism, tumor microenvironment and tumor stem cells also have played an important role in drug resistance in ovarian cancer. The strategy targeting these mechanisms has provided a new method to increase sensitivity to chemotherapy and improve the prognosis. |
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| Keywords: | Ovarian cancer Drug resistance Mechanism Targeted treatment |
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