Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. |
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| Authors: | G Conn M L Bayne D D Soderman P W Kwok K A Sullivan T M Palisi D A Hope K A Thomas |
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| Affiliation: | Department of Biochemistry, Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065. |
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| Abstract: | Glioma-derived vascular endothelial cell growth factor (GD-VEGF) is a 46-kDa dimeric glycoprotein mitogen with apparently greater specificity for vascular endothelial cells than the well-characterized fibroblast growth factors. The GD-VEGF cDNA sequence encodes a 190-amino acid residue subunit that is converted, by removal of an amino-terminal hydrophobic secretory leader sequence, to the mature 164-residue subunit characterized by direct amino acid sequencing. The GD-VEGF homodimeric subunit is homologous to the platelet-derived growth factor A and B chains and its oncogene homologue v-sis. |
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