| 去铁酮在大鼠体内的药代动力学与组织分布 |
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| 引用本文： | 巩泉泉,刘萍,张雅楠,徐华雷,李玉彩,贾晓静. 去铁酮在大鼠体内的药代动力学与组织分布[J]. 中国药理学与毒理学杂志, 2010, 24(1): 59-63. DOI: 10.3867/j.issn.1000-3002.2010.01.010 |
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| 作者姓名： | 巩泉泉 刘萍 张雅楠 徐华雷 李玉彩 贾晓静 |
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| 作者单位： | 山东大学公共卫生学院卫生检验研究所,山东,济南,250012 |
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| 基金项目： | 山东省自然科学基金资助项目 |
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| 摘 要： | 目的研究去铁酮(DFP)在大鼠体内的药代动力学和组织分布。方法雄性Wistar大鼠ig给予DFP35,70和140mg.kg-1后,于不同时间点收集血液和组织样本。采用高效液相色谱法测定大鼠血浆及组织中的DFP的含量,运用DAS2.0药代动力学智能分析软件拟合房室模型,并进行药代动力学参数计算。结果大鼠ig给予DFP35,70和140mg.kg-1后,体内药代动力学过程符合二室模型,t1/2α分别为23.3,22.2和20.9min,t1/2β分别为53.3,50.9和46.3min,Cl分别为0.017,0.021和0.016L.min-1.kg-1。大鼠ig给予DFP70mg.kg-1后,DFP在胃和肝中浓度较高,60min时肝中DFP含量可达(359.22±31.16)μg.g-1,其他组织含量较低。结论DFP在大鼠体内吸收和消除较迅速,在体内组织分布广。
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| 关 键 词： | 去铁酮 色谱法,高效液相 药代动力学 |
| 收稿时间： | 2009-06-02 |
Pharmacokinetics and tissue distribution of deferiprone in rats |
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| GONG Quan-quan,LIU Ping,ZHANG Ya-nan,XU Hua-lei,LI Yu-cai,JIA Xiao-jing. Pharmacokinetics and tissue distribution of deferiprone in rats[J]. Chinese Journal of Pharmacology and Toxicology, 2010, 24(1): 59-63. DOI: 10.3867/j.issn.1000-3002.2010.01.010 |
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| Authors: | GONG Quan-quan LIU Ping ZHANG Ya-nan XU Hua-lei LI Yu-cai JIA Xiao-jing |
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| Affiliation: | (Department of Chemistry and Microbacteria Detection, College of Public Health, Shandong University, Jinan 250012, China) |
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| Abstract: | OBJECTIVE To study the pharmacokinetics and tissue distribution of deferiprone (DFP) in rats. METHODS Plasma and tissues were collected after male Wistar rats were ig given DFP 35, 70 and 140 mg·kg~(-1) at different time points. The DFP in plasma and tissues was determined by high performance liquid chromatography. The compartment model was fitted and pharmacokinetic parameters were calculated by DAS 2.0. RESULTS The results showed that the pharmacokinetic process of DFP in rats was two-compartment model after rats were ig given DFP 35, 70 and 140 mg·kg~(-1). The t_(1/2α) were 23.3, 22.2 and 20.9 min, respectively. The t_(1/2β) were 53.3, 50.9 and 46.3 min, respectively. The Cl were 0.017, 0.021 and 0.016 L·min~(-1)·kg~(-1), respectively. The content of DFP was high in stomach and liver tissues after rats were ig given DFP 70 mg·kg~(-1), and it was lower in the other tissues. The content of DFP in liver tissues was (359.22±31.16)μg·g~(-1), at 60 min after rats were ig given DFP 70 mg·kg~(-1). CONCLUSION The absorption and elimination of DFP are quick and the tissue distribution of DFP is wide in vivo. |
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| Keywords: | deferiprone chromatography high-performance liquid pharmacokinetics |
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